AIMC Topic: Anti-Inflammatory Agents, Non-Steroidal

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Machine learning risk prediction model for acute coronary syndrome and death from use of non-steroidal anti-inflammatory drugs in administrative data.

Scientific reports Sep 15, 2021
Our aim was to investigate the usefulness of machine learning approaches on linked administrative health data at the population level in predicting older patients' one-year risk of acute coronary syndrome and death following the use of non-steroidal ...
Humans Machine Learning Prognosis Female Risk Factors Male Area Under Curve Cause of Death Disease Management Acute Coronary Syndrome Proportional Hazards Models Disease Susceptibility Risk Assessment Comorbidity ROC Curve Models, Theoretical Australia Anti-Inflammatory Agents, Non-Steroidal
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A machine learning approach identifies 5-ASA and ulcerative colitis as being linked with higher COVID-19 mortality in patients with IBD.

Scientific reports Aug 13, 2021
Inflammatory bowel diseases (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammation within the gastrointestinal tract. IBD patient conditions and treatments, such as with immunosuppressants, may result in a higher risk...
Child, Preschool Child United States Anti-Inflammatory Agents, Non-Steroidal Databases, Factual Mesalamine Inflammatory Bowel Diseases Sulfasalazine Female Young Adult Infant, Newborn Aged Humans Adult Aged, 80 and over Machine Learning Male COVID-19 Middle Aged Infant Adolescent
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Evaluation of Effect of Curcumin on Psychological State of Patients with Pulmonary Hypertension by Magnetic Resonance Image under Deep Learning.

Contrast media & molecular imaging Jul 26, 2021
This research aimed to evaluate the right ventricular segmentation ability of magnetic resonance imaging (MRI) images based on deep learning and evaluate the influence of curcumin (Cur) on the psychological state of patients with pulmonary hypertensi...
Adolescent Follow-Up Studies Magnetic Resonance Imaging Anti-Inflammatory Agents, Non-Steroidal Curcumin Hypertension, Pulmonary Adult Male Middle Aged Anxiety Disorders Case-Control Studies Deep Learning Depressive Disorder Humans Neural Networks, Computer Algorithms Female Aged Young Adult
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Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort.

PLoS computational biology Jul 6, 2021
Drug-drug interactions account for up to 30% of adverse drug reactions. Increasing prevalence of electronic health records (EHRs) offers a unique opportunity to build machine learning algorithms to identify drug-drug interactions that drive adverse e...
Female Aged Aged, 80 and over Young Adult Adult Male Humans Machine Learning Algorithms Retrospective Studies Electronic Health Records Anti-Inflammatory Agents, Non-Steroidal Middle Aged Drug Interactions Adolescent Chemical and Drug Induced Liver Injury Computational Biology Liver Models, Statistical
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A Machine Learning Approach to Identify Predictors of Potentially Inappropriate Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Use in Older Adults with Osteoarthritis.

International journal of environmental research and public health Dec 28, 2020
Evidence from some studies suggest that osteoarthritis (OA) patients are often prescribed non-steroidal anti-inflammatory drugs (NSAIDs) that are not in accordance with their cardiovascular (CV) or gastrointestinal (GI) risk profiles. However, no suc...
United States Anti-Inflammatory Agents, Non-Steroidal Medicare Osteoarthritis Gastrointestinal Diseases Inappropriate Prescribing Retrospective Studies Female Aged Aged, 80 and over Male Cardiovascular Diseases Humans Machine Learning
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Perioperative Outcomes of Patients Who Were Not Candidates for Additional Nonsteroidal Anti-inflammatory Drugs in a Multimodal Pain Control Regimen for Total Knee Arthroplasty.

Clinics in orthopedic surgery Dec 21, 2020
BACKGROUD: Postoperative pain following total knee arthroplasty (TKA) may hamper patients from a rapid recovery and increase perioperative blood loss and stress on the cardiovascular system. Therefore, our objective was to assess perioperative outcom...
Analgesia, Patient-Controlled Arthroplasty, Replacement, Knee Middle Aged Humans Celecoxib Anti-Inflammatory Agents, Non-Steroidal Retrospective Studies Cyclooxygenase 2 Inhibitors Pain Measurement Female Isoxazoles Pain, Postoperative Aged Pain Management Analgesics, Opioid Male Morphine
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Automatic detection of erosions and ulcerations in wireless capsule endoscopy images based on a deep convolutional neural network.

Gastrointestinal endoscopy Oct 25, 2018
BACKGROUND AND AIMS: Although erosions and ulcerations are the most common small-bowel abnormalities found on wireless capsule endoscopy (WCE), a computer-aided detection method has not been established. We aimed to develop an artificial intelligence...
ROC Curve Humans Aged, 80 and over Ileal Diseases Anti-Inflammatory Agents, Non-Steroidal Adult Neural Networks, Computer Intestine, Small Area Under Curve Software Sensitivity and Specificity Jejunal Diseases Pattern Recognition, Automated Inflammatory Bowel Diseases Male Peptic Ulcer Female Middle Aged Capsule Endoscopy Ulcer Aged Deep Learning Duodenal Ulcer
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Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.

Journal of colloid and interface science Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Ibuprofen Anhydrides Fumarates Rabbits Hydrogen-Ion Concentration Animals Polyethylene Glycols Humans Hydrolysis Nanoparticles Solubility Cell Line Micelles Drug Liberation Prodrugs Cell Survival HeLa Cells Drug Carriers Hydrophobic and Hydrophilic Interactions Anti-Inflammatory Agents, Non-Steroidal Polypropylenes Surface Properties
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Gene Expression Regulation Proliferating Cell Nuclear Antigen Cyclooxygenase 2 Cartilage, Articular Matrix Metalloproteinase 3 Primary Cell Culture Achyranthes bcl-Associated Death Protein bcl-X Protein NF-kappa B Matrix Metalloproteinase 9 bcl-2-Associated X Protein Chondrocytes Male Saponins Plant Extracts Tumor Suppressor Protein p53 Animals Rats Apoptosis Inflammation Caspase 3 Signal Transduction Anti-Inflammatory Agents, Non-Steroidal Rats, Sprague-Dawley Plant Roots Interleukin-1beta
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Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities.

Bioorganic & medicinal chemistry Dec 29, 2016
A new series of 11-keto-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid analogs (5, 7, 8, 10, 13, 18a-d, 27a-c, 28a-d) were synthesized by modification of hydroxyl and acid functional moieties of boswellic acids. The structures of these anal...
Humans Dose-Response Relationship, Drug Structure-Activity Relationship Anti-Inflammatory Agents, Non-Steroidal Molecular Structure Triterpenes Arachidonate 5-Lipoxygenase Lipoxygenase Inhibitors
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