AIMC Topic: Anti-Inflammatory Agents
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IF-AIP: A machine learning method for the identification of anti-inflammatory peptides using multi-feature fusion strategy.
Computers in biology and medicine
Nov 19, 2023
BACKGROUND: The most commonly used therapy currently for inflammatory and autoimmune diseases is nonspecific anti-inflammatory drugs, which have various hazardous side effects. Recently, some anti-inflammatory peptides (AIPs) have been found to be a ...
Anti-inflammatory and antioxidative actions of tacrolimus (FK506) on human microglial HMC3 cell line.
Scandinavian journal of immunology
Nov 13, 2023
Microglial cells are indispensable for the normal development and functioning of neurons in the central nervous system, where they play a crucial role in maintaining brain homeostasis by surveilling the microenvironment for signs of injury or stress ...
High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads.
Chembiochem : a European journal of chemical biology
Nov 7, 2023
We developed a high-content image-based screen that utilizes the pro-inflammatory stimulus lipopolysaccharide (LPS) and murine macrophages (RAW264.7) with the goal of enabling the identification of novel anti-inflammatory lead compounds. We screened ...
Anti-inflammatory and urease inhibitory iridoid glycosides from Nyctanthes arbor-tristis Linn.
Journal of ethnopharmacology
Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Nyctanthes arbor-tristis Linn. has been used by Ayruvedic physicians for the cure of different diseases including ulcers, gastric and inflammatory diseases.
E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.
Journal of ethnopharmacology
Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Stroke
Infarction, Middle Cerebral Artery
DNA-Binding Proteins
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Anti-Infective Agents
Tumor Necrosis Factor-alpha
Lipopolysaccharides
Plant Leaves
Microglia
Interleukin-6
Neuroinflammatory Diseases
Rats
NF-kappa B
Inflammation
Animals
Anti-Inflammatory Agents
Rats, Sprague-Dawley
Mice
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo.
Journal of ethnopharmacology
Oct 28, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Artemisia argyi has been used medicinally and eaten for more than 2000 years in China. It is widely reported in treating inflammatory diseases such as eczema, dermatitis, arthritis, a...
Anti-inflammatory therapy enables robot-actuated regeneration of aged muscle.
Science robotics
Mar 22, 2023
Robot-actuated mechanical loading (ML)-based therapies ("mechanotherapies") can promote regeneration after severe skeletal muscle injury, but the effectiveness of such approaches during aging is unknown and may be influenced by age-associated decline...
Solubility Optimization of Loxoprofen as a Nonsteroidal Anti-Inflammatory Drug: Statistical Modeling and Optimization.
Molecules (Basel, Switzerland)
Jul 7, 2022
Industrial-based application of supercritical CO (SCCO) has emerged as a promising technology in numerous scientific fields due to offering brilliant advantages, such as simplicity of application, eco-friendliness, and high performance. Loxoprofen so...
Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects.
Molecular medicine reports
Apr 1, 2022
Evodiamine (Evo) is an alkaloid that can be extracted from the berry fruit and has been reported to exert various pharmacological effects, such as antidiarrheal, antiemetic and antiulcer effects. , the potential effects of Evo were investigated in a...
Gibberellic acid-induced hepatorenal dysfunction and oxidative stress: Mitigation by quercetin through modulation of antioxidant, anti-inflammatory, and antiapoptotic activities.
Journal of food biochemistry
Jan 5, 2022
The plant growth regulator gibberellic acid (GA3) is widely used in agriculture in many countries. However, little is known about its danger to human health or its physiologic and biochemical pathways. Our study examined the effect of GA3 on liver an...
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