AIMC Topic: Asthma

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Development of a machine learning-based depression risk identification tool for older adults with asthma.

BMC psychiatry
BACKGROUND: Asthma is a chronic inflammatory disorder that adversely affects the quality of life, particularly in older adults. The coexistence of depression in asthma patients complicates their management and exacerbates health outcomes. This study ...

Artesunate alleviates chronic allergic rhinitis and asthma syndrome via the CCR3/NF-κB pathway: a comprehensive analysis.

International immunopharmacology
BACKGROUND: Chronic allergic rhinitis and asthma syndrome (CARAS) is a comorbid inflammatory condition affecting both upper and lower airways, with limited treatment options. Artesunate (ART), a derivative of artemisinin, has shown anti-inflammatory ...

3,6'-Disinapoyl sucrose modulates GALE-mediated metabolic reprogramming to alleviate asthmatic airway inflammation.

International immunopharmacology
BACKGROUND: Asthma is a heterogeneous disease characterized by chronic airway inflammation and metabolic dysregulation. Recent studies highlight the role of glycolysis and oxidative phosphorylation (OXPHOS) imbalance in asthma pathogenesis, yet the u...

Investigation into the Classification of Cough Sounds for Early Asthma Screening.

Current allergy and asthma reports
PURPOSE OF REVIEW: This review aims to explore an effective and scalable approach for early asthma detection using cough sounds. The main objective is to evaluate whether a multi-model deep learning fusion framework can improve diagnostic accuracy an...

A hybrid approach for forecasting peak expiratory flow rate in asthma patients using combined linear regression and random forest model.

PloS one
Asthma is a frequent and long-lasting disorder associated with airway inflammation. The disease severity may lead to serious health concerns and even mortality. In this work, we propose a novel hybrid approach using machine learning models and simila...

Predictive modeling of asthma drug properties using machine learning and topological indices in a MATLAB based QSPR study.

Scientific reports
Machine learning is a vital tool in advancing drug development by accurately predicting the physical, chemical, and biological properties of various compounds. This study utilizes MATLAB program-based algorithms to calculate topological indices and m...

Non-invasive acoustic classification of adult asthma using an XGBoost model with vocal biomarkers.

Scientific reports
Traditional diagnostic methods for asthma, a widespread chronic respiratory illness, are often limited by factors such as patient cooperation with spirometry. Non-invasive acoustic analysis using machine learning offers a promising alternative for ob...

Anoikis-related biomarkers PARP1 and SDCBP as diagnostic and therapeutic targets for asthma.

Scientific reports
This study aims to explore the association between anoikis-related genes (ARGs) and asthma. The dataset GSE143303 for asthma were sourced from the GEO database, while ARGs were retrieved from the Harmonizome web portal and the GeneCards database. Dif...

Identifying and characterising asthma subgroups at high risk of severe exacerbations using machine learning and longitudinal real-world data.

BMJ health & care informatics
OBJECTIVES: To identify and characterise distinct subgroups of patients with asthma with severe acute exacerbations (AEs) by using a multistep clustering methodology that combines supervised and unsupervised machine learning.

Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry.

BMJ open respiratory research
INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibili...