AIMC Topic: Biological Availability
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Bioequivalence of fixed-dose combinations of dapagliflozin and metformin with single-component tablets in healthy subjects and the effect of food on bioavailability.
Clinical pharmacology in drug development
Oct 20, 2015
The pharmacokinetics (PK) of dapagliflozin and metformin administered as fixed-dose combination (FDC) tablets (2.5 mg dapagliflozin/850 mg metformin or 5 mg dapagliflozin/1000 mg metformin) or as separate tablets in healthy subjects were evaluated in...
Pharmacokinetics of aclidinium bromide/formoterol fumarate fixed-dose combination compared with individual components: A phase 1, open-label, single-dose study.
Clinical pharmacology in drug development
Aug 24, 2015
Inhaled, long-acting bronchodilators represent a cornerstone of maintenance treatment for chronic obstructive pulmonary disease (COPD). Aclidinium bromide/formoterol fumarate 400/12 μg fixed-dose combination (FDC) has recently been licensed for use i...
Absolute oral bioavailability and pharmacokinetics of canagliflozin: A microdose study in healthy participants.
Clinical pharmacology in drug development
Dec 11, 2014
Absolute oral bioavailability of canagliflozin was assessed by simultaneous oral administration with intravenous [(14) C]-canagliflozin microdose infusion in nine healthy men. Pharmacokinetics of canagliflozin, [(14) C]-canagliflozin, and total radio...
Integrating machine learning and traditional methods for cadmium prediction and bioavailability assessment in Paeoniae Radix Alba: a case study from Bozhou, Anhui Province.
Environmental geochemistry and health
May 21, 2025
Soil heavy metal contamination, particularly cadmium (Cd), poses a significant risk to ecosystems and human health. This study investigates the distribution and bioavailability of Cd in soil and Paeoniae Radix Alba system from Qiaocheng District, Boz...
Application of Machine Learning Technology in the Prediction of ADME- Related Pharmacokinetic Parameters.
Current medicinal chemistry
Jan 1, 2023
BACKGROUND: As an important determinant in drug discovery, the accurate analysis and acquisition of pharmacokinetic parameters are very important for the clinical application of drugs. At present, the research and development of new drugs mainly obta...
Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...
Artificial neural network and bioavailability of the immunosuppression drug.
Current opinion in organ transplantation
Aug 1, 2020
PURPOSE OF REVIEW: The success of organ transplant is determined by number of demographic, clinical, immunological and genetic variables. Artificial intelligence tools, such as artificial neural networks (ANNs) or classification and regression trees ...
Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease.
Chinese journal of natural medicines
Jan 1, 2018
Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and...
THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.
Acta poloniae pharmaceutica
May 1, 2017
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy c...
Area Under Curve
Drug Monitoring
Models, Biological
Spectrophotometry, Ultraviolet
Antipyretics
Humans
Chromatography, High Pressure Liquid
Male
Biological Availability
Acetaminophen
Female
Middle Aged
Half-Life
Analgesics, Non-Narcotic
Aged
Kidney
Kidney Neoplasms
Nephrectomy
Aged, 80 and over
Infusions, Intravenous
Metabolic Clearance Rate
Renal Elimination
Adult
The Effect of Vitamin D Supplementation on Metabolic Phenotypes in Thais with Prediabetes.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
Dec 1, 2015
OBJECTIVE: To investigate the effects of vitamin D supplement for three months on anthropometric and glucose homeostatic measures in Thai adults with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT).
Vitamins
Calcifediol
Asian People
Tandem Mass Spectrometry
Biological Availability
Treatment Outcome
Dietary Supplements
Regression Analysis
Drug Monitoring
Ergocalciferols
Glucose Tolerance Test
Anthropometry
Cholecalciferol
Prediabetic State
Humans
Phenotype
Female
Adult
Male
Middle Aged
Insulin Resistance
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