Sepsis is a life-threatening condition resulting from a dysregulated immune response to infection, often leading to organ failure and death. Early detection is vital, as delays significantly worsen outcomes. In recent years, the integration of artifi...
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is marked by the accumulation of amyloid-β (Aβ) plaques. Although cerebral Aβ positron emission tomography (Aβ-PET) remains the gold standard for assessing cerebral Aβ burden, i...
BACKGROUND: Type 2 diabetes (T2D) and its vascular complications, including diabetic retinopathy (DR), are escalating in prevalence globally, with disproportionately high prevalence in Middle Eastern populations, where genetic predispositions and lif...
BACKGROUND: Serum lipase levels are crucial biomarkers in acute pancreatitis (AP), yet their dynamic patterns and prognostic implications remain incompletely understood. This study aimed to identify distinct lipase trajectory phenotypes and evaluate ...
OBJECTIVE: This study investigated the relationship between estimated glucose disposal rate (eGDR), aging acceleration (AgeAccel), and mortality in adults diagnosed with cardiovascular-kidney-metabolic (CKM) stages 1 to 4.
Rapid and accurate diagnosis of emerging inflammatory illnesses is challenging due to overlapping clinical features with existing conditions. We demonstrate an approach that integrates proteomic analysis with machine learning to identify diagnostic p...
Bronchopulmonary dysplasia (BPD) remains a debilitating disease in premature infants. The chronic pathogenesis of BPD with complex prenatal and postnatal programming challenges attempts at precisely defining or treating disease. While existing BPD de...
BACKGROUND: We aimed to create a Machine learning (ML) model using patient demographic, clinical and pathological data for prediction of overall survival in patients treated with radical cystectomy (RC). Secondly, we evaluated whether inflammatory ma...
Clinica chimica acta; international journal of clinical chemistry
Oct 18, 2025
BACKGROUND: Alzheimer's disease (AD), a neurodegenerative disorder with multifactorial etiologies, has been closely associated with disturbances in manganese metabolism. However, its specific biomarkers remain insufficiently characterized. This study...
Severe COVID-19 often progresses to critical illness, requiring accurate prognostic biomarkers. Lactate-to-albumin ratio (LAR) has been proposed as a novel indicator to estimate the likelihood of death. Using data from the MIMIC database, this retros...
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