Psychogenic erectile dysfunction (pED) is a prevalent male sexual dysfunction lacking organic etiology. Endeavors have been made in previous studies to disclose the brain pathological mechanisms of pED. However, the cortical morphological characteris...
BACKGROUND: Depression is a mental health condition that affects millions of people worldwide. Although common, it remains difficult to diagnose due to its heterogeneous symptomatology. Mental health questionnaires are currently the most used assessm...
Locomotor learning is important for improving gait and balance impairments in people with Parkinson's disease (PD). While PD disrupts neural networks involved in motor learning, there is a limited understanding of how PD influences the time course of...
BACKGROUND: Visual cognitive impairment is among the most common postoperative cognitive dysfunctions, significantly impacting recovery and quality of life in elderly patients. However, effective preoperative prediction methods remain lacking. We dev...
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. Symptoms related to CRC can be non-sp...
Journal of pharmaceutical and biomedical analysis
Jul 25, 2025
Primary Sjögren's Syndrome (pSS) is a complex autoimmune disease with an unclear etiology. Due to the lack of a single diagnostic gold standard, multidisciplinary and invasive examinations are often required for pSS, underscoring the urgent need for ...
We evaluated whether predicted continuous disease representations could enhance genetic discovery beyond case-control genome-wide association study (GWAS) phenotypes across eight complex diseases in up to 485,448 UK Biobank participants. Predicted ph...
Motor outcomes in Parkinson's disease (PD) have long been the primary diagnostic criteria and treatment targets. While non-motor outcomes of PD impact daily well-being, they are rarely targeted by interventions or utilized for classification. Despite...
The specific role of lysophospholipids (LysoPLs) in the pathogenesis of chronic obstructive pulmonary disease (COPD) is not yet fully understood. We determined serum LysoPLs in 20 patients with stable COPD and 20 healthy smokers using liquid chromato...
Rheumatoid arthritis (RA) is a systemic inflammatory condition posing challenges in identifying biomarkers for onset, severity and treatment responses. Here we investigate the plasma proteome in a longitudinal cohort of 278 RA patients, alongside 60 ...
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