AIMC Topic: Case-Control Studies
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Genetic association studies using disease liabilities from deep neural networks.
American journal of human genetics
Feb 21, 2025
The case-control study is a widely used method for investigating the genetic underpinnings of binary traits. However, long-term, prospective cohort studies often grapple with absent or evolving health-related outcomes. Here, we propose two methods, l...
Multi-cancer early detection based on serum surface-enhanced Raman spectroscopy with deep learning: a large-scale case-control study.
BMC medicine
Feb 21, 2025
BACKGROUND: Early detection of cancer can help patients with more effective treatments and result in better prognosis. Unfortunately, established cancer screening technologies are limited for use, especially for multi-cancer early detection. In this ...
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation.
Clinical epigenetics
Feb 17, 2025
BACKGROUND: The changes in DNA methylation patterns may reflect both physical and mental well-being, the latter being a relatively unexplored avenue in terms of clinical utility for psychiatric disorders. In this study, our objective was to identify ...
Predicting antipsychotic responsiveness using a machine learning classifier trained on plasma levels of inflammatory markers in schizophrenia.
Translational psychiatry
Feb 14, 2025
We apply machine learning techniques to navigate the multifaceted landscape of schizophrenia. Our method entails the development of predictive models, emphasizing peripheral inflammatory biomarkers, which are classified into treatment response subgro...
A metabolic fingerprint of ovarian cancer: a novel diagnostic strategy employing plasma EV-based metabolomics and machine learning algorithms.
Journal of ovarian research
Feb 12, 2025
Ovarian cancer (OC) is the third most common malignant tumor of women and is accompanied by an alteration of systemic metabolism. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids has great potential for OC diagnosis. ...
Interpretable machine learning-derived nomogram model for early detection of persistent diarrhea in Salmonella typhimurium enteritis: a propensity score matching based case-control study.
BMC infectious diseases
Feb 10, 2025
BACKGROUND: Salmonella typhimurium infection is a considerable global health concern, particularly in children, where it often leads to persistent diarrhea. This condition can result in severe health complications including malnutrition and cognitive...
Contrast-enhanced magnetic resonance imaging based calf muscle perfusion and machine learning in peripheral artery disease.
Scientific reports
Feb 10, 2025
Peripheral artery disease (PAD) remains underdiagnosed and undertreated and is associated with an increased risk for adverse cardiovascular outcomes. Imaging provides an approach to identifying patients with PAD. However, the role of integrating imag...
Unveiling NLR pathway signatures: EP300 and CPN60 markers integrated with clinical data and machine learning for precision NASH diagnosis.
Cytokine
Feb 8, 2025
BACKGROUND: Given the increasing prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and non-alcoholic steatohepatitis (NASH), there is a critical need for accurate non-invasive early diagnostic markers.
You get the best of both worlds? Integrating deep learning and traditional machine learning for breast cancer risk prediction.
Computers in biology and medicine
Feb 5, 2025
Breast Cancer is the most commonly diagnosed cancer worldwide. While screening mammography diminishes the burden of this disease, it has some flaws related to the presence of false negatives. Adapting screening to each woman's needs could help overco...
Untargeted metabolomics and machine learning unveil the exposome and metabolism linked with the risk of early pregnancy loss.
Journal of hazardous materials
Jan 31, 2025
Early pregnancy loss (EPL) may result from exposure to emerging contaminants (ECs), although the underlying mechanisms remain poorly understood. This case-control study measured over 2000 serum features, including 37 ECs, 6 biochemicals, and 2057 end...
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