AIMC Topic: Cell Line
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Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description.
BioMed research international
Dec 9, 2015
Bovine papillomavirus (BPV) is considered a useful model to study HPV oncogenic process. BPV interacts with the host chromatin, resulting in DNA damage, which is attributed to E5, E6, and E7 viral oncoproteins activity. However, the oncogenic mechani...
Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.
PLoS computational biology
Aug 7, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phos...
Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.
PLoS neglected tropical diseases
Jun 26, 2015
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System.
Journal of visualized experiments : JoVE
May 14, 2015
Continued advancement in pluripotent stem cell culture is closing the gap between bench and bedside for using these cells in regenerative medicine, drug discovery and safety testing. In order to produce stem cell derived biopharmaceutics and cells fo...
Printing 2-dimentional droplet array for single-cell reverse transcription quantitative PCR assay with a microfluidic robot.
Scientific reports
Apr 1, 2015
This paper describes a nanoliter droplet array-based single-cell reverse transcription quantitative PCR (RT-qPCR) assay method for quantifying gene expression in individual cells. By sequentially printing nanoliter-scale droplets on microchip using a...
Evaluation of combinations of in vitro sensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization.
Journal of applied toxicology : JAT
Mar 30, 2015
The skin sensitization potential of chemicals has been determined with the use of the murine local lymph node assay (LLNA). However, in recent years public concern about animal welfare has led to a requirement for non-animal risk assessment systems f...
Identification of active transcriptional regulatory elements from GRO-seq data.
Nature methods
Mar 23, 2015
Modifications to the global run-on and sequencing (GRO-seq) protocol that enrich for 5'-capped RNAs can be used to reveal active transcriptional regulatory elements (TREs) with high accuracy. Here, we introduce discriminative regulatory-element detec...
Use of uniform designs in combination with neural networks for viral infection process development.
Biotechnology progress
Jan 27, 2015
This work aimed to compare the predictive capacity of empirical models, based on the uniform design utilization combined to artificial neural networks with respect to classical factorial designs in bioprocess, using as example the rabies virus replic...
Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes.
Bioprocess and biosystems engineering
Jan 1, 2015
Currently, mammalian cells are the most utilized hosts for biopharmaceutical production. The culture media for these cell lines include commonly in their composition a pH indicator. Spectroscopic techniques are used for biopharmaceutical process moni...
Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.
Biochimica et biophysica acta
Nov 13, 2014
Understanding the processes of mitochondrial dynamics (fission, fusion, biogenesis, and mitophagy) has been hampered by the lack of automated, deterministic methods to measure mitochondrial morphology from microscopic images. A method to quantify mit...
Electron Transport
tert-Butylhydroperoxide
Carbonyl Cyanide m-Chlorophenyl Hydrazone
Cell Respiration
Animals
Sodium-Potassium-Exchanging ATPase
Imaging, Three-Dimensional
Stress, Physiological
Mice
Cell Membrane
Cell Line
Cell Survival
Artificial Intelligence
Membrane Potential, Mitochondrial
Phenotype
Oxidants
Mitochondria
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