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Clinical Trials as Topic

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Cohort selection for clinical trials using deep learning models.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: The goal of the 2018 n2c2 shared task on cohort selection for clinical trials (track 1) is to identify which patients meet the selection criteria for clinical trials. Cohort selection is a particularly demanding task to which natural langu...

Evaluating shallow and deep learning strategies for the 2018 n2c2 shared task on clinical text classification.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Automated clinical phenotyping is challenging because word-based features quickly turn it into a high-dimensional problem, in which the small, privacy-restricted, training datasets might lead to overfitting. Pretrained embeddings might sol...

Medical knowledge infused convolutional neural networks for cohort selection in clinical trials.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: In this era of digitized health records, there has been a marked interest in using de-identified patient records for conducting various health related surveys. To assist in this research effort, we developed a novel clinical data represent...

Cohort selection for clinical trials using hierarchical neural network.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Cohort selection for clinical trials is a key step for clinical research. We proposed a hierarchical neural network to determine whether a patient satisfied selection criteria or not.

Clinical trial cohort selection based on multi-level rule-based natural language processing system.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Identifying patients who meet selection criteria for clinical trials is typically challenging and time-consuming. In this article, we describe our clinical natural language processing (NLP) system to automatically assess patients' eligibil...

Hybrid bag of approaches to characterize selection criteria for cohort identification.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: The 2018 National NLP Clinical Challenge (2018 n2c2) focused on the task of cohort selection for clinical trials, where participating systems were tasked with analyzing longitudinal patient records to determine if the patients met or did n...

Optimizing clinical trials recruitment via deep learning.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Clinical trials, prospective research studies on human participants carried out by a distributed team of clinical investigators, play a crucial role in the development of new treatments in health care. This is a complex and expensive proce...

Enabling Data-Driven Clinical Quality Assurance: Predicting Adverse Event Reporting in Clinical Trials Using Machine Learning.

Drug safety
INTRODUCTION: Adverse event (AE) under-reporting has been a recurrent issue raised during health authorities Good Clinical Practices (GCP) inspections and audits. Moreover, safety under-reporting poses a risk to patient safety and data integrity. The...