BACKGROUND: Multi-drug combinations represent an effective strategy for treating complex diseases. However, due to the vast number of unknown interactions among drugs, accurately predicting drug-drug interactions (DDIs) is essential for preventing ad...
Cancer molecular subtype classification is an essential component of precision oncology which provides insights into cancer prognosis and guides targeted therapy. Despite the growing applications of AI for cancer molecular subtype classification, cha...
Journal of chemical information and modeling
Dec 18, 2025
Natural products, synthesized via enzymes encoded by biosynthetic gene clusters (BGCs), represent a major source of therapeutic agents. Accurate BGC annotation is essential to unlocking the vast potential of natural product diversity. However, BGC an...
Biochemical and biophysical research communications
Dec 17, 2025
The dry fruits of Amomum villosum (Av) are a traditional Chinese medicine used for gastrointestinal disease. Aromatic oil has been reported to have anti-tumor properties. However, its therapeutic potential and molecular mechanisms remain unclear. Int...
Biochemical and biophysical research communications
Dec 16, 2025
BACKGROUND: Multiple sclerosis (MS) and psoriasis are both immune-mediated inflammatory diseases. Previous studies have reported comorbidity between MS and psoriasis, but the underlying mechanisms remain unclear. This study aims to elucidate the shar...
Osteoarthritis (OA) is a chronic joint disorder characterized by cartilage degradation and accompanied by inflammatory processes. Inflammation and autophagy dysfunction have been associated with the pathogenesis of OA. However, the interplay between ...
Big biological datasets, such as gene expression profiles, often contain redundant features that degrade model performance and limit generalization across independent datasets with complexities like class imbalance and hidden sub-clusters. To overcom...
Journal of chemical information and modeling
Dec 10, 2025
Promoter sequences across species exhibit both specificity and conservation. The specificity of promoter sequences typically leads to lower cross-species prediction performance compared to within-species prediction. However, conserved promoter motifs...
Journal of chemical information and modeling
Dec 8, 2025
MiRNA serves as a key noncoding RNA regulating gene expression and is frequently targeted as a therapeutic small molecule (SM). However, relying solely on the experimental identification of SM-miRNA interactions proves costly and inefficient. To addr...
Journal of chemical information and modeling
Dec 8, 2025
With the continued exploration of biological resources in extreme environments, functional proteins such as acidophilic proteins have attracted increasing attention. These proteins can maintain structural stability and biological functionality under ...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.