AIMC Topic: Computational Biology
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Potential diagnostic and therapeutic gene in chronic low back pain through pyroptosis modulation: A silico study based on the dataset analysis.
Scientific reports
Jul 16, 2025
Chronic low back pain (cLBP ) is a common condition that affects the quality of life, can be caused by disc degeneration, facet arthropathy, myofascial pain, sacroiliac joint pain, spondyloarthropathies, and nociplastic pain etc. Research suggests th...
EUP: Enhanced cross-species prediction of ubiquitination sites via a conditional variational autoencoder network based on ESM2.
PLoS computational biology
Jul 16, 2025
Ubiquitination is critical in biomedical research. Predicting ubiquitination sites based on deep learning model have advanced the study of ubiquitination. However, traditional supervised model limits in the scenarios where labels are scarcity across ...
Prediction of pathogenic mutations in human transmembrane proteins and their associated diseases via utilizing pre-trained Bio-LLMs.
Communications biology
Jul 15, 2025
Missense mutations can disrupt the structure and function of membrane proteins, potentially impairing key biological processes and leading to various human diseases. However, existing computational methods primarily focus on binary pathogenicity clas...
BertADP: a fine-tuned protein language model for anti-diabetic peptide prediction.
BMC biology
Jul 15, 2025
BACKGROUND: Diabetes is a global metabolic disease that urgently calls for the development of new and effective therapeutic agents. Anti-diabetic peptides (ADPs) have emerged as a research hotspot due to their therapeutic potential and natural safety...
How large is the universe of RNA-like motifs? A clustering analysis of RNA graph motifs using topological descriptors.
PLoS computational biology
Jul 15, 2025
Identifying novel and functional RNA structures remains a significant challenge in RNA motif design and is crucial for developing RNA-based therapeutics. Here we introduce a computational topology-based approach with unsupervised machine-learning alg...
Identification and analysis of pyroptosis-related key genes in heart failure.
Journal of cardiothoracic surgery
Jul 14, 2025
BACKGROUND: Pyroptosis plays a pivotal role in the pathogenesis of Heart Failure (HF). However, the current understanding of how pyroptosis-related genes (PRGs) influence HF is scarce. This study aimed to explore the link between PRGs and HF based on...
Integrating AI and CRISPR Cas13a for rapid detection of tomato brown rugose fruit virus.
Scientific reports
Jul 14, 2025
The Tomato Brown Rugose Fruit Virus (ToBRFV) has recently emerged as a serious threat to global tomato production, underscoring the need for rapid and sensitive diagnostic tools. Here, we present an AI-driven CRISPR-Cas13a pipeline for designing crRN...
Integrated bioinformatics and machine learning reveal key genes and immune mechanisms associated with uremia.
Scientific reports
Jul 14, 2025
Uremia is a serious complication of end-stage chronic kidney disease, closely associated with immune imbalance and chronic inflammation. However, its molecular mechanisms remain largely unclear. In this study, we analyzed transcriptomic data from the...
Identification of diagnostic biomarkers and dissecting immune microenvironment with crosstalk genes in the POAG and COVID-19 nexus.
Scientific reports
Jul 12, 2025
An underlying association between primary open-angle glaucoma (POAG) and COVID-19 has been hypothesized, but the causal link and shared mechanisms remain unclear. This study integrates epidemiological and bioinformatics approaches to investigate thei...
Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence.
Nature communications
Jul 12, 2025
The rise of antibiotic-resistant pathogens, particularly gram-negative bacteria, highlights the urgent need for novel therapeutics. Drug-resistant infections now contribute to approximately 5 million deaths annually, yet traditional antibiotic discov...
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