AIMC Topic: DNA, Mitochondrial

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Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.

Scientific reports Jul 1, 2025
Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Br...
Female SARS-CoV-2 Risk Factors Aged Humans COVID-19 Genetic Predisposition to Disease DNA, Mitochondrial Mitochondria Haplotypes Adult Male Middle Aged Brazil
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Screening mitochondria-related biomarkers in skin and plasma of atopic dermatitis patients by bioinformatics analysis and machine learning.

Frontiers in immunology May 7, 2024
BACKGROUND: There is a significant imbalance of mitochondrial activity and oxidative stress (OS) status in patients with atopic dermatitis (AD). This study aims to screen skin and peripheral mitochondria-related biomarkers, providing insights into th...
Mitochondria Dermatitis, Atopic Machine Learning Gene Expression Profiling Humans Biomarkers Computational Biology Female Skin Male DNA, Mitochondrial
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Identification and verification of diagnostic biomarkers based on mitochondria-related genes related to immune microenvironment for preeclampsia using machine learning algorithms.

Frontiers in immunology Jan 8, 2024
Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality worldwide. Preeclampsia is linked to mitochondrial dysfunction as a contributing factor in its progression. This study aimed to develop a novel diagnostic model b...
Mitochondria Pregnancy Humans Female Machine Learning Pre-Eclampsia Algorithms DNA, Mitochondrial Biomarkers
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Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography.

BMC genomics May 7, 2022
BACKGROUND: We combined an unsupervised learning methodology for analyzing mitogenome sequences with maximum likelihood (ML) phylogenetics to make detailed inferences about the evolution and diversification of mitochondrial DNA (mtDNA) haplogroup U5,...
Humans Phylogeny Europe Haplotypes Evolution, Molecular Phylogeography Unsupervised Machine Learning Genetics, Population Bayes Theorem DNA, Mitochondrial
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A new linear combination method of haplogroup distribution central vectors to model population admixtures.

Molecular genetics and genomics : MGG Apr 11, 2022
We introduce a novel population genetic approach suitable to model the origin and relationships of populations, using new computation methods analyzing Hg frequency distributions. Hgs were selected into groups which show correlated frequencies in sub...
Artificial Intelligence Algorithms Phylogeny Genetics, Population DNA, Mitochondrial Mercury Haplotypes Hungary
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The application of machine learning to predict genetic relatedness using human mtDNA hypervariable region I sequences.

PloS one Feb 18, 2022
Human identification of unknown samples following disaster and mass casualty events is essential, especially to bring closure to family and friends of the deceased. Unfortunately, victim identification is often challenging for forensic investigators ...
Forensic Genetics DNA, Mitochondrial Polymorphism, Genetic Racial Groups Pedigree Humans Machine Learning
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MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data.

PLoS computational biology Nov 11, 2021
The growing number of next-generation sequencing (NGS) data presents a unique opportunity to study the combined impact of mitochondrial and nuclear-encoded genetic variation in complex disease. Mitochondrial DNA variants and in particular, heteroplas...
Humans Machine Learning Big Data Genes, Mitochondrial DNA, Mitochondrial High-Throughput Nucleotide Sequencing
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Diagnosis of Wilson Disease and Its Phenotypes by Using Artificial Intelligence.

Biomolecules Aug 20, 2021
WD is caused by variants disrupting copper efflux resulting in excessive copper accumulation mainly in liver and brain. The diagnosis of WD is challenged by its variable clinical course, onset, morbidity, and variant type. Currently it is diagnosed...
Glutamic Acid Copper-Transporting ATPases Hepatolenticular Degeneration Ceruloplasmin Copper Mutation DNA, Mitochondrial Medical Informatics Artificial Intelligence Humans Female Diagnosis, Computer-Assisted Algorithms Neural Networks, Computer Adult Fuzzy Logic Phenotype Male Liver Brain Middle Aged Principal Component Analysis
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Machine-learning to stratify diabetic patients using novel cardiac biomarkers and integrative genomics.

Cardiovascular diabetology Jun 11, 2019
BACKGROUND: Diabetes mellitus is a chronic disease that impacts an increasing percentage of people each year. Among its comorbidities, diabetics are two to four times more likely to develop cardiovascular diseases. While HbA1c remains the primary dia...
Models, Genetic Prognosis Mitochondria, Heart Support Vector Machine Female Middle Aged Genomics Diabetic Cardiomyopathies DNA Methylation Risk Factors Genetic Markers Humans Genetic Predisposition to Disease Male DNA, Mitochondrial CpG Islands Systems Integration Polymorphism, Single Nucleotide Epigenesis, Genetic Glycated Hemoglobin Risk Assessment Disease Progression Diabetes Mellitus, Type 2
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A single nucleotide polymorphism panel for individual identification and ancestry assignment in Caucasians and four East and Southeast Asian populations using a machine learning classifier.

Forensic science, medicine, and pathology Jan 16, 2019
Single nucleotide polymorphism (SNP) profiling is an effective means of individual identification and ancestry inferences in forensic genetics. This study established a SNP panel for the simultaneous individual identification and ancestry assignment ...
Gene Frequency Humans Asia Machine Learning Chromosomes, Human, Y Female Retrospective Studies DNA Fingerprinting Genetics, Population Male Chromosomes, Human, X Support Vector Machine Polymorphism, Single Nucleotide DNA Degradation, Necrotic DNA, Mitochondrial Genotype Asian People White People
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