AIMC Topic: Extracellular Vesicles
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Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles.
Nature aging
Dec 6, 2021
Heterochronic blood exchange (HBE) has demonstrated that circulating factors restore youthful features to aged tissues. However, the systemic mediators of those rejuvenating effects remain poorly defined. We show here that the beneficial effect of yo...
Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells.
Journal of advanced research
Nov 19, 2021
INTRODUCTION: The regenerative capacity of mesenchymal stromal cells or medicinal signaling cells (MSCs) is largely mediated by their secreted small extracellular vesicles (sEVs), and the therapeutic efficacy of sEVs can be enhanced by licensing appr...
Converging Multidimensional Sensor and Machine Learning Toward High-Throughput and Biorecognition Element-Free Multidetermination of Extracellular Vesicle Biomarkers.
ACS sensors
Jul 7, 2020
Extracellular vesicles (EVs) are a frontier class of circulating biomarkers for the diagnosis and prognosis of different diseases. These lipid structures afford various biomarkers such as the concentrations of the EVs () themselves and carried protei...
Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics.
Journal of neurotrauma
May 6, 2019
The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in the type and severity of injuries and the multiple endophenotypes that describe each patient's response and recovery to the injury. It has been challenging t...
Extending gene ontology in the context of extracellular RNA and vesicle communication.
Journal of biomedical semantics
Apr 12, 2016
BACKGROUND: To address the lack of standard terminology to describe extracellular RNA (exRNA) data/metadata, we have launched an inter-community effort to extend the Gene Ontology (GO) with subcellular structure concepts relevant to the exRNA domain....
Developing a Two-Dimensional Size-Exclusion Liquid Chromatography Platform for Isolating the High-Quality Extracellular Vesicles to Predict and Evaluate Metabolic Improvement Outcomes of Sleeve Gastrectomy.
Analytical chemistry
Jul 15, 2025
The direct analysis of plasma exosomal components still presents significant challenges due to the interference of high concentrations of albumin, immunoglobulins, and other abundant proteins. Herein, we developed a two-dimensional size-exclusion liq...
Extracellular vesicles as nature's nano carriers in cancer therapy: Insights toward preclinical studies and clinical applications.
Pharmacological research
Jul 1, 2025
Extracellular vesicles (EVs), which are secreted by various cell types, hold significant potential for cancer therapy. However, there are several challenges and difficulties that limit their application in clinical settings. This review, which integr...
Enhanced Early Detection of Colorectal Cancer via Blood Biomarker Combinations Identified Through Extracellular Vesicle Isolation and Artificial Intelligence Analysis.
Journal of extracellular vesicles
Jun 1, 2025
Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide, with early detection being crucial for improving survival rates. Despite the potential of extracellular vesicles (EVs) as blood biomarkers for CRC diagnosis, their clin...
Accurate Cancer Diagnosis and Treatment Monitoring through Multiplexed Profiling of Protein Markers on Small Extracellular Vesicles.
ACS nano
May 20, 2025
The detection of small extracellular vesicles (sEVs) is currently a pivotal liquid biopsy approach for noninvasive cancer diagnosis. However, the lack of adequate specificity and sensitivity, as well as labor-intensive purification and analysis proce...
Machine learning-assisted washing-free detection of extracellular vesicles by target recycling amplification based fluorescent aptasensor for accurate diagnosis of gastric cancer.
Talanta
May 15, 2025
Extracellular vesicles (EVs) are promising non-invasive biomarkers for cancer diagnosis. EVs proteins play a critical role in tumor progress and metastasis. However, accurately and reliably diagnosing cancers is greatly limited by single protein mark...
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