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Machine learning-based prediction of mortality risk in AIDS patients with comorbid common AIDS-related diseases or symptoms.

Frontiers in public health
OBJECTIVE: Early assessment and intervention of Acquired Immune Deficiency Syndrome (AIDS) patients at high risk of mortality is critical. This study aims to develop an optimally performing mortality risk prediction model for AIDS patients with comor...

S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning.

Molecular psychiatry
The impact of general anesthetics on neurodevelopment is highly controversial in terms of clinical and preclinical studies. Evidence mounted in recent years indicated development of social cognitions was more susceptible to general anesthesia in earl...

Assessing GPT-4's accuracy in answering clinical pharmacological questions on pain therapy.

British journal of clinical pharmacology
AIMS: This study aimed to evaluate the accuracy and completeness of GPT-4, a large language model, in answering clinical pharmacological questions related to pain therapy, with a focus on its potential as a tool for delivering patient-facing medical ...

Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.

Cellular signalling
OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute panc...

Use and Usefulness of Risk Prediction Tools in Urologic Surgery: Current State and Path Forward.

Urology practice
INTRODUCTION: Although the enthusiasm for artificial intelligence (AI) to enhance surgical decision-making continues to grow, the preceding advance of risk prediction tools (RPTs) has had limited impact to date. To help inform the development of AI-p...

Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis.

Journal of affective disorders
BACKGROUND: Major Depressive Disorder (MDD) and Bipolar Disorder (BD) exhibit overlapping depressive symptoms, complicating their differentiation in clinical practice. Traditional neuroimaging studies have focused on specific regions of interest, but...

Early differential diagnosis models of Talaromycosis and Tuberculosis in HIV-negative hosts using clinical data and machine learning.

Journal of infection and public health
BACKGROUND: Talaromyces marneffei is an emerging pathogen, and the number of infections in HIV-negative individuals is increasing. In HIV-negative individuals, talaromycosis is usually misdiagnosed as another disease, especially tuberculosis (TB).

A machine learning approach using gait parameters to cluster TKA subjects into stable and unstable joints for discovery analysis.

The Knee
BACKGROUND: Patient-reported joint instability after total knee arthroplasty (TKA) is difficult to quantify objectively. Here, we apply machine learning to cluster TKA subjects using nine literature-proposed gait parameters as knee instability predic...