Prostate cancer (PCa) progression is driven by complex molecular reprogramming, yet distinguishing indolent from aggressive disease remains a challenge. We performed an integrative transcriptomic analysis of 1232 PCa samples spanning normal prostate ...
Osteoarthritis (OA) is a chronic joint disorder characterized by cartilage degradation and accompanied by inflammatory processes. Inflammation and autophagy dysfunction have been associated with the pathogenesis of OA. However, the interplay between ...
BACKGROUND: Sepsis and atrial fibrillation are complex, life-threatening medical conditions affecting approximately 49 million individuals globally, characterized by exceptionally high mortality rates. Lipid metabolism abnormalities play a critical r...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and neuroinflammation, with emerging roles of peripheral immune dysregulation in disease progression. This study aimed to investigate the regulatory ne...
BACKGROUND: Hepatic ischemia-reperfusion injury (HIRI) represents the leading cause of postoperative liver dysfunction and failure. Ammonia-induced cell death (ACD), defined by lysosomal and mitochondrial disruption due to intracellular ammonia accum...
BACKGROUND: Numerous studies have manifested that cellular senescence involves in the pathogenesis of intervertebral disc degeneration (IDD). Here, we constructed a novel senescence-related genes (SRGs) signature for IDD.
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with complex underlying mechanisms. PANoptosis, a newly defined form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis, may play a crucial ...
Acute myocardial infarction (AMI) triggered cardiomyocyte senescence and impaired cardiac function. Methylation modifications and related enzymes in patients were also significantly altered, but the association between cellular senescence and demethy...
Inferring gene regulatory networks (GRNs) is essential for understanding biological regulation. Although numerous deep learning approaches have been developed for GRN inference, most require large amounts of labeled data. We present Meta-TGLink, a st...
Head and neck cancers represent a critical global health issue, contributing to substantial morbidity and mortality. Recent research has explored the role of microRNAs (miRNAs) in these cancers by constructing miRNA-associated disease networks using ...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.