AIMC Topic: Gene Regulatory Networks
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Integrated multi-omics analysis and machine learning refine molecular subtypes and prognosis in hepatocellular carcinoma through O-linked glycosylation genes.
Functional & integrative genomics
Jul 28, 2025
O-glycosylation significantly influences cellular physiological processes and disease regulation by modulating the structure, function, and stability of proteins. However, there is a notable gap in research focusing on O-glycosylation in relation to ...
Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.
Scientific reports
Jul 20, 2025
Cerebral amyloid angiopathy (CAA) and insomnia are age-related neurological disorders increasingly recognized as being closely associated. However, research on the shared genes and their biological mechanisms remains limited. This study aims to ident...
Identification of clinical diagnostic and immune cell infiltration characteristics of acute myocardial infarction with machine learning approach.
Scientific reports
Jul 20, 2025
Acute myocardial infarction (AMI) is a serious heart disease with high fatality rates. The progress of AMI involves immune cell infiltration. However, suitable clinical diagnostic biomarkers and the roles of immune cells in AMI remain unknown. Three ...
Prediction of hub genes in pulpal inflammation and regeneration using autoencoders and a generative AI approach.
Scientific reports
Jul 19, 2025
Pulpal inflammation and regeneration are crucial for enhancing endodontic treatment outcomes. Transcriptomic studies highlight the involvement of proinflammatory cytokines, NF-κB signaling, and stem cell activity. This study employs a generative AI a...
Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach.
Scientific reports
Jul 18, 2025
Ischemic stroke (IS) affects 11 million people annually, posing substantial clinical and economic burdens. Current therapies remain limited by time sensitivity and variable efficacy, necessitating novel biomarkers. We developed a multi-omics framewor...
Shared pathogenic mechanisms linking obesity and idiopathic pulmonary fibrosis revealed by bioinformatics and in vivo validation.
Scientific reports
Jul 17, 2025
Previous studies have suggested a potential correlation between obesity and idiopathic pulmonary fibrosis (IPF). This study aimed to elucidate pathogenic pathways connecting obesity and IPF and identify diagnostic biomarkers for obesity-related pulmo...
Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization.
Scientific reports
Jul 17, 2025
Liver cirrhosis (LC) is a common chronic disease worldwide with a poor prognosis, and its pathogenesis has not been fully elucidated. Toll-like receptors (TLRs) are crucial in LC progression. Here, we identified TLR-related genes, providing novel ins...
Cross-attention graph neural networks for inferring gene regulatory networks with skewed degree distribution.
BMC bioinformatics
Jul 16, 2025
BACKGROUND: Inferring Gene Regulatory Networks (GRNs) from gene expression data is a pivotal challenge in systems biology. Most existing methods fail to consider the skewed degree distribution of genes, complicating the application of directed graph ...
Multi-tissue Methylation Analysis of Alzheimer's Disease: Insights into Pathways, Modules, and Key Genes.
Journal of molecular neuroscience : MN
Jul 16, 2025
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...
Potential diagnostic and therapeutic gene in chronic low back pain through pyroptosis modulation: A silico study based on the dataset analysis.
Scientific reports
Jul 16, 2025
Chronic low back pain (cLBP ) is a common condition that affects the quality of life, can be caused by disc degeneration, facet arthropathy, myofascial pain, sacroiliac joint pain, spondyloarthropathies, and nociplastic pain etc. Research suggests th...
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