AI Medical Compendium Topic

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Genotype

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Machine learning approaches and genetic determinants that influence the development of type 2 diabetes mellitus: a genetic association study in Brazilian patients.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
This genetic association study including 120 patients with type 2 diabetes mellitus (T2DM) and 166 non-diabetic individuals aimed to investigate the association of polymorphisms in the genes GSTM1 and GSTT1 (gene deletion), GSTP1 (rs1695), ACE (rs464...

Discovering genotype-phenotype relationships with machine learning and the Visual Physiology Opsin Database (VPOD).

GigaScience
BACKGROUND: Predicting phenotypes from genetic variation is foundational for fields as diverse as bioengineering and global change biology, highlighting the importance of efficient methods to predict gene functions. Linking genetic changes to phenoty...

Predicting laboratory aspirin resistance in Chinese stroke patients using machine learning models by GP1BA polymorphism.

Pharmacogenomics
This study aims to use machine learning model to predict laboratory aspirin resistance (AR) in Chinese stroke patients by incorporating patient characteristics and single nucleotide polymorphisms of and . 2405 patients were analyzed to measure the M...

ProTformer: Transformer-based model for superior prediction of protein content in lablab bean (Lablab purpureus L.) using Near-Infrared Reflectance spectroscopy.

Food research international (Ottawa, Ont.)
Lablab bean (Lablab purpureus L.), known for its higher protein content provides a promising alternative to reduce reliance on animal-based proteins and support sustainable agriculture. Nowadays, traditional methods for nutritional profiling have bee...

Machine learning-enhanced multi-trait genomic prediction for optimizing cannabinoid profiles in cannabis.

The Plant journal : for cell and molecular biology
Cannabis sativa L., known for its medicinal and psychoactive properties, has recently experienced rapid market expansion but remains understudied in terms of its fundamental biology due to historical prohibitions. This pioneering study implements GS ...

Neural network-based predictions of antimicrobial resistance phenotypes in multidrug-resistant from whole genome sequencing and gene expression.

Antimicrobial agents and chemotherapy
Whole genome sequencing (WGS) potentially represents a rapid approach for antimicrobial resistance genotype-to-phenotype prediction. However, the challenge still exists to predict fully minimum inhibitory concentrations (MICs) and antimicrobial susce...

Barley Grain Proteome Assessment Using Multi-Environment Trial Data and Machine Learning.

Journal of agricultural and food chemistry
Proteomics can be used to assess individual protein abundances, which could reflect genotypic and environmental effects and potentially predict grain/malt quality. In this study, 79 barley grain samples (genotype-location-year combinations) from Cali...

Improving methylmalonic acidemia (MMA) screening and MMA genotype prediction using random forest classifier in two Chinese populations.

European journal of medical research
BACKGROUND: Methylmalonic acidemia (MMA) is one of the most common hereditary organic acid metabolism disorders that endangers the lives and health of infants and children. Early detection and intervention before the appearance of a newborn's clinica...

Cropformer: An interpretable deep learning framework for crop genomic prediction.

Plant communications
Machine learning and deep learning are extensively employed in genomic selection (GS) to expedite the identification of superior genotypes and accelerate breeding cycles. However, a significant challenge with current data-driven deep learning models ...