AIMC Topic: Hep G2 Cells

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Identification of disease-specific genes related to immune infiltration in nonalcoholic steatohepatitis using machine learning algorithms.

Medicine May 17, 2024
To identify disease signature genes associated with immune infiltration in nonalcoholic steatohepatitis (NASH), we downloaded 2 publicly available gene expression profiles, GSE164760 and GSE37031, from the gene expression omnibus database. These prof...
Humans Transcriptome Support Vector Machine Hep G2 Cells Non-alcoholic Fatty Liver Disease Machine Learning Algorithms Gene Expression Profiling
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Iterative feature representation algorithm to improve the predictive performance of N7-methylguanosine sites.

Briefings in bioinformatics Jul 20, 2021
MOTIVATION: N7-methylguanosine (m7G) is an important epigenetic modification, playing an essential role in gene expression regulation. Therefore, accurate identification of m7G modifications will facilitate revealing and in-depth understanding their ...
DNA Methylation Humans HeLa Cells Guanosine Epigenesis, Genetic Support Vector Machine Hep G2 Cells
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Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports Mar 17, 2020
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...
Female Animals Swine United States Humans Machine Learning Food Diterpenes Glucuronosyltransferase ATP Binding Cassette Transporter, Subfamily B, Member 1 Retinyl Esters Hep G2 Cells Drug Interactions Mice, Inbred BALB C Abietanes Pharmaceutical Preparations Excipients Biological Assay United States Food and Drug Administration
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Toxic activity of Prunus spinosa L. flower extract in hepatocarcinoma cells.

Arhiv za higijenu rada i toksikologiju Dec 1, 2019
Prunus spinosa L. (blackthorn) is used in traditional medicine as a remedy for various diseases. To establish its anticancer properties, we exposed human liver cancer cells (Hep G2) to a range of blackthorn flower extract concentrations (10-200 µg/mL...
Reactive Oxygen Species Plant Extracts Croatia Hep G2 Cells Humans Prunus Apoptosis Liver Neoplasms Flowers Carcinoma, Hepatocellular
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Modeling positional effects of regulatory sequences with spline transformations increases prediction accuracy of deep neural networks.

Bioinformatics (Oxford, England) Apr 15, 2018
MOTIVATION: Regulatory sequences are not solely defined by their nucleic acid sequence but also by their relative distances to genomic landmarks such as transcription start site, exon boundaries or polyadenylation site. Deep learning has become the a...
Proteins DNA RNA K562 Cells Models, Genetic Sequence Analysis, DNA Hep G2 Cells Regulatory Sequences, Nucleic Acid Humans Neural Networks, Computer Machine Learning Genomics Sequence Analysis, RNA Software Protein Binding
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Antioxidant and antiproliferative activities of protein hydrolysate from the rhizomes of Zingiberaceae plants.

Pakistan journal of pharmaceutical sciences Nov 1, 2016
Plant proteins have been investigated for their antioxidant activities, but there are still no reports detailing the antioxidant activity levels of plants in the Zingiberaceae family, which are popular food agents and used in folklore medicine. In th...
Molecular Weight Inhibitory Concentration 50 Plant Proteins Chromatography, Ion Exchange Rhizome Protein Hydrolysates Plant Extracts Phytotherapy Humans Cell Proliferation Plants, Medicinal Hep G2 Cells Neoplasms Antineoplastic Agents, Phytogenic Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Biphenyl Compounds Dose-Response Relationship, Drug Antioxidants Ascorbic Acid Picrates Zingiberaceae
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Effect of Fanbaicao (Herba Potentillae Discoloris) oil on the expression of p21 and CDK4 in HepG2 cells.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To research the anti-cancer mechanism of the Traditional Chinese Medicine Fanbaicao (Herba Potentillae Discoloris) oil in the human hepatoma cell line HepG2.
Drugs, Chinese Herbal Liver Neoplasms Cell Cycle Cyclin-Dependent Kinase 4 Hep G2 Cells Humans Cell Proliferation Potentilla Cyclin-Dependent Kinase Inhibitor p21 Apoptosis
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LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.

Oncotarget Nov 24, 2015
Accumulating evidences suggest that long non-coding RNAs (lncRNAs) perform important functions. Genome-wide chromatin-states area rich source of information about cellular state, yielding insights beyond what is typically obtained by transcriptome pr...
Histones Gene Ontology Chromatin Transcription Initiation Site Promoter Regions, Genetic RNA, Messenger Lysine Models, Genetic Neoplasms K562 Cells Hep G2 Cells Gene Expression Profiling HeLa Cells Humans Cell Line, Tumor Cell Line Methylation Algorithms Gene Regulatory Networks RNA, Long Noncoding Cells, Cultured
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