Image aesthetics assessment (IAA) has become a hot research area in recent years due to its extensive application potential. However, existing IAA methods often overlook the importance of spatial information in evaluating image aesthetics. To address...
BACKGROUND: Integrating engineering design processes into science education has become a significant priority in STEM instruction. However, many science teachers face difficulties incorporating these processes due to limited pedagogical expertise. Ge...
Liver cancer, particularly hepatocellular carcinoma (HCC), remains a significant health burden with poor survival rates due to late diagnosis and limited treatment options. Sorafenib, a multi-kinase inhibitor, is the standard first-line therapy for a...
Systems biology in reproductive medicine
Sep 21, 2025
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder affecting numerous women of reproductive age, characterized by a variety of clinical and biochemical features. Accurate classification and diagnosis of PCOS remains challenging due to t...
Oestrogen receptor alpha (ERα)-positive (ER+) breast cancers are driven by the binding of 17β-oestradiol (E2) to ERα, which transcriptionally regulates target genes. Although microarrays and conventional RNA sequencing have identified E2 target genes...
OBJECTIVES: To investigate the correlation between fat-to-muscle ratio (FMR) or other body composition and secondary osteoporosis (OP) in patients with rheumatoid arthritis (RA) and to develop a predictive model using FMR and related clinical factors...
Bone cancer pain (BCP) is a complex condition that severely affects patients' quality of life, and its treatment remains challenging. Astaxanthin, a potent antioxidant with anti-inflammatory and neuroprotective effects, and celecoxib, a selective COX...
Artificial intelligence and machine learning are revolutionizing pharmaceutical research by enabling the rapid analysis of complex datasets and automating critical tasks throughout the drug-development process. In this review, we surveyed how artific...
To address the toxicity of current microtubule inhibitors, we employed the GeminiMol deep learning model to screen the Zinc20 database, identifying a novel 4,5-dihydropyrrolo[3,4-]pyrazol-6(2)-one scaffold () targeting the colchicine binding site. Su...
Clinica chimica acta; international journal of clinical chemistry
Sep 19, 2025
Extracellular vesicles, particularly exosomes, are emerging as powerful tools in cancer research due to their role in intercellular communication and their capacity to reflect the molecular composition of their originating cells. Multi-omic approache...
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