Pituitary neuroendocrine tumors (PitNETs) represent approximately 16% of primary brain tumors. Tumor consistency, whether soft or hard, directly affects surgical strategy, extent of resection, and risk of complications. This study aimed to perform a ...
Proteomics has become a transformative tool in oncology, offering unique opportunities for early detection, diagnosis, and cancer stratification. By enabling large-scale analysis of protein expression, interactions, and post-translational modificatio...
BACKGROUND: Pre-mRNA alternative splicing contributes to oncogenic gene expression in hepatocellular carcinoma (HCC), and some oncogenic isoforms escape the tumor into circulation. This study aimed to characterize the alternative splicing landscape o...
Large language models (LLMs), such as ChatGPT, have demonstrated impressive performance on general medical examinations; however, their effectiveness significantly declines in specialized board examinations due to limited domain-specific training dat...
Array-based biosensors hold substantial promise for rapid bacterial identification. However, conventional approaches face two key limitations: their reliance on nonspecific interactions with bacterial surfaces hinders biochemical interpretation, and ...
Proceedings of the National Academy of Sciences of the United States of America
Dec 12, 2025
Brain-inspired spiking neural networks (SNNs) have garnered significant research attention in algorithm design and perception applications. However, their potential in the decision-making domain, particularly in model-based reinforcement learning, re...
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common complication after type A aortic dissection surgery and often leads to worsened clinical outcomes for patients. The early prediction of postoperative ARDS is a crucial challenge in cl...
BACKGROUND: Artificial intelligence is emerging as a transformative force in pharmaceutical sciences by enabling data-driven decision-making, automation, and predictive modeling. In ocular drug delivery, where therapeutic efficacy is hindered by comp...
BACKGROUND: Urolithiasis, particularly anhydrous uric acid stones (AUAs), imposes significant clinical and economic burdens. Accurate preoperative differentiation of AUAs from other stone types remains challenging, yet essential for personalized pati...
BACKGROUND: Opioid overuse is a costly and significant problem in the United States. Medical specialties including surgery are a contributor to opioid prescriptions while having few clear prescribing guidelines. Machine learning predictive tools can ...
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