Artificial Intelligence (AI) is widely used in various fields, including the health system and related sciences, as one of the significant advances in technology. Many efforts are being made to improve the prevention, diagnosis, prediction, treatment...
Journal of chemical information and modeling
May 30, 2025
Cell-to-cell communication (CCC) is prominent for cell growth and development as well as tissue and organ formation. CCC inference can help us to deeply understand cellular interplay and discover potential therapeutic targets for complex diseases. Ce...
Donor-specific antibodies (DSAs) against human leukocyte antigen (HLA) play a crucial role in antibody-mediated rejection, a major barrier to successful organ transplantation. Donor-recipient HLA molecular incompatibility critically influences DSA su...
Early childhood caries (ECC) exhibits tooth specificity, highlighting the need for single-tooth-level prevention. We profiled 2,504 dental plaque microbiota samples from 89 preschoolers across two cohorts, tracking compositional changes with imputed ...
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are criti...
Proceedings of the National Academy of Sciences of the United States of America
May 30, 2025
The rise of foundation models marks a paradigm shift in machine learning: instead of training specialized models from scratch, foundation models are trained on massive datasets before being adjusted or fine-tuned to make predictions on smaller datase...
International journal of biological macromolecules
May 30, 2025
MRGPRX1 plays dual roles in mediating nociception and pruritus, making it a promising target for alleviating itch and inhibiting pain. However, the mechanisms underlying MRGPRX1 activation and allosteric modulation remain poorly understood, posing si...
Understanding the dynamics of complex, whole-body interpersonal coordination behavior in humans is an important subject in behavioral science. However, due to the challenges of analyzing complex causal relationships among multiple body components wit...
PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non-small cell lung cancer (NSCLC). Current diagnostic methods, including imaging and histopathology, have limited sensitivity and specificity. This stud...
Theory in biosciences = Theorie in den Biowissenschaften
May 30, 2025
The Price equation provides a formal account of selection building on a right-total mapping between two classes of individuals, which is usually interpreted as a parent-offspring relation. This paper presents a new formulation of the Price equation i...
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