AIMC Topic: Ibuprofen
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TCoCPIn reveals topological characteristics of chemical protein interaction networks for novel feature discovery.
Scientific reports
May 18, 2025
Understanding chemical-protein interactions (CPIs) is crucial for drug discovery and biological research, yet their complexity often challenges traditional methods. We propose TCoCPIn, a novel framework integrating graph neural networks (GNN) with th...
Prediction of micropollutant degradation kinetic constant by ultrasonic using machine learning.
Chemosphere
Jun 24, 2024
A prediction model based on XGBoost is proposed for ultrasonic degradation of micropollutants' kinetic constants. After parameter optimization through iteration, the model achieves Evaluation metrics with R and SMAPE reaching 0.99 and 2.06%, respecti...
Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen.
Molecules (Basel, Switzerland)
May 14, 2024
Deep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or bet...
Unveiling the potential of machine learning in cost-effective degradation of pharmaceutically active compounds: A stirred photo-reactor study.
Chemosphere
May 5, 2024
In this study, neural networks and support vector regression (SVR) were employed to predict the degradation over three pharmaceutically active compounds (PhACs): Ibuprofen (IBP), diclofenac (DCF), and caffeine (CAF) within a stirred reactor featuring...
Biphasic burst and sustained transdermal delivery in vivo using an AI-optimized 3D-printed MN patch.
International journal of pharmaceutics
Feb 6, 2023
The objective of the present study was to fabricate microneedles for delivering lipophilic active ingredients (APIs) using digital light processing (DLP) printing technology and quality by design (QbD) supplemented by artificial intelligence (AI) alg...
Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy.
Journal of pharmaceutical and biomedical analysis
Jun 4, 2018
The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine-nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC...
Carbamazepine
Polyvinyls
Ibuprofen
Niacinamide
Absorption, Physicochemical
Calibration
Spectroscopy, Fourier Transform Infrared
Crystallization
Neural Networks, Computer
Least-Squares Analysis
Chemistry, Pharmaceutical
Machine Learning
Polyethylene Glycols
Spectrum Analysis, Raman
Drug Compounding
Drug Combinations
Analysis of ibuprofen and its main metabolites in roots, shoots, and seeds of cowpea (Vigna unguiculata L. Walp) using liquid chromatography-quadrupole time-of-flight mass spectrometry: uptake, metabolism, and translocation.
Analytical and bioanalytical chemistry
Dec 29, 2017
A liquid chromatography quadruple time-of-flight mass spectrometry (LC-QqTOF-MS/MS) method was developed for simultaneous quantitative analysis of ibuprofen (IBU), 1- and 2-hydroxyibuprofen (1-OH IBU and 2-OH IBU), and carboxyibuprofen (CBX IBU) whil...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Hydrolysis
Surface Properties
Prodrugs
Humans
Anti-Inflammatory Agents, Non-Steroidal
Ibuprofen
Solubility
HeLa Cells
Animals
Anhydrides
Rabbits
Drug Liberation
Hydrophobic and Hydrophilic Interactions
Fumarates
Nanoparticles
Micelles
Hydrogen-Ion Concentration
Polypropylenes
Cell Line
Polyethylene Glycols
Cell Survival
Drug Carriers
Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets.
Acta pharmaceutica (Zagreb, Croatia)
Jun 27, 2017
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeD...
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