AIMC Topic: Immunoglobulin G
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COVID-19 IgG/IgM patterns, early IL-6 elevation and long-term radiological sequelae in 75 patients hospitalized due to interstitial pneumonia followed up from 3 to 12 months.
PloS one
Feb 22, 2022
BACKGROUND: COVID-19 pandemic resulted in about 165 million infections and 3.4 million deaths all over the world across 15 months. The most severe clinical presentation of COVID-19 diseases is interstitial pneumonia.
Specific IgE and IgG4 Profiles of House Dust Mite Components in Allergen-Specific Immunotherapy.
Frontiers in immunology
Feb 7, 2022
BACKGROUND: Allergen immunotherapy (AIT) can induce immune tolerance to allergens by activating multiple mechanisms, including promoting IgG4 synthesis and blunting IgE production. However, the longitudinal data of sIgE and sIgG4 to allergen componen...
NIgPred: Class-Specific Antibody Prediction for Linear B-Cell Epitopes Based on Heterogeneous Features and Machine-Learning Approaches.
Viruses
Aug 3, 2021
Upon invasion by foreign pathogens, specific antibodies can identify specific foreign antigens and disable them. As a result of this ability, antibodies can help with vaccine production and food allergen detection in patients. Many studies have focus...
Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.
PLoS computational biology
May 3, 2021
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
Immunoglobulin G
Computer Simulation
Animals
Single-Cell Analysis
Neural Networks, Computer
Interleukin-4
STAT6 Transcription Factor
Supervised Machine Learning
Databases, Nucleic Acid
Models, Immunological
Receptors, Cytokine
Recombination, Genetic
Basic-Leucine Zipper Transcription Factors
Signal Transduction
RNA-Seq
Immunoglobulin Class Switching
Mice, Inbred C57BL
Mice
NF-kappa B p50 Subunit
Gene Expression
Computational Biology
B-Lymphocytes
Machine Learning to Quantify Humoral Selection in Human Lupus Tubulointerstitial Inflammation.
Frontiers in immunology
Nov 27, 2020
In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear. Herein, we demonstrate that AVA somatic hypermut...
Prediction of 3-month treatment outcome of IgG4-DS based on BP artificial neural network.
Oral diseases
Sep 13, 2020
OBJECTIVE: The study aimed to establish an effective back-Propagation artificial neural network (BP-ANN) model for automatic prediction of 3-month treatment outcome of IgG4-DS.
Absolute quantitation of high abundant Fc-glycopeptides from human serum IgG-1.
Analytica chimica acta
Dec 18, 2019
Absolute quantitation of IgG-1 Fc-glycosylation, which is crucial for the clinical practice of glyco-biomarkers and quality control of biopharmaceuticals, has been hindered by the lack of glycopeptide standards. In this study, eleven high abundant Ig...
Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis.
Iranian journal of allergy, asthma, and immunology
Oct 23, 2019
The relationship between high levels of anti-Varicella Zoster Virus (VZV) IgG in cerebrospinal fluid (CSF) and cerebrovascular atherosclerosis commends a possible similar association in other vessels. We aimed to investigate the association of VZV-se...
Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study.
Journal of infection in developing countries
May 31, 2019
INTRODUCTION: Despite high population immunity, pertussis remains one of the leading causes of vaccine-preventable deaths worldwide. The aim of this study was to determine the seroprevalence of IgG antibodies to pertussis toxin (PT) and diphtheria am...
Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning.
Analytical chemistry
Dec 14, 2018
Bispecific antibodies are regarded as the next generation of therapeutic modalities as they can simultaneously bind multiple targets, increasing the efficacy of treatments for several diseases and opening up previously unattainable treatment designs....
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