Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, because this requires additional genetic or immunohis...
BACKGROUND: Targeting epitopes derived from neo-antigens (or "neo-epitopes") represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 +...
Computer methods and programs in biomedicine
Mar 8, 2019
BACKGROUND AND OBJECTIVES: In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment...
Proinflammatory cytokines have the capacity to increase inflammatory reaction and play a central role in first line of defence against invading pathogens. Proinflammatory inducing peptides (PIPs) have been used as an antineoplastic agent, an antibact...
European journal of clinical investigation
Feb 19, 2018
BACKGROUND: Lung cancer is the leading cause of cancer death worldwide. In up to 57% of patients, it is diagnosed at an advanced stage and the 5-year survival rate ranges between 10%-16%. There has been a significant amount of research using machine ...
Vitamin D deficiency has been reported to be a negative prognostic factor in elderly patients with aggressive B-cell lymphomas. In vitro data suggest that vitamin D supplementation may enhance rituximab-mediated cytotoxicity. We prospectively assesse...
Otolaryngologic clinics of North America
May 17, 2017
Precision medicine is the application of genotypic and Omics biomarkers to determine the most appropriate, outcome-driven therapy for individual patients. To determine the best choice of therapy, institutions use significant information technology-en...
As benign tumors, warts are made through the mediation of Human Papillomavirus (HPV) and may grow on all parts of body, especially hands and feet. There are several treatment methods for this illness. However, none of them can heal all patients. Cons...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nov 15, 2025
We pioneer a multimodal framework integrating single-cell RNA sequencing (scRNA-seq), radiomics, and deep learning to decipher dendritic cell (DC)-mediated mechanisms underlying anti-PD-1 response in non-small cell lung cancer (NSCLC). Single-cell RN...
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