AIMC Topic: Inflammation

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Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders.

Scientific reports
Tyrosine-protein kinase Src plays a key role in cell proliferation and growth under favorable conditions, but its overexpression and genetic mutations can lead to the progression of various inflammatory diseases. Due to the specificity and selectivit...

Fibrosis and inflammatory activity diagnosis of chronic hepatitis C based on extreme learning machine.

Scientific reports
The traditional diagnosis of chronic hepatitis C usually relies on liver biopsy. Diagnosing chronic hepatitis C based on serum indices provides a non-invasive way to determine the stage of chronic hepatitis C without liver biopsy. In this paper, we p...

Performance analysis of a deep-learning algorithm to detect the presence of inflammation in MRI of sacroiliac joints in patients with axial spondyloarthritis.

Annals of the rheumatic diseases
OBJECTIVES: To assess the ability of a previously trained deep-learning algorithm to identify the presence of inflammation on MRI of sacroiliac joints (SIJ) in a large external validation set of patients with axial spondyloarthritis (axSpA).

Predictive modeling of ICU-AW inflammatory factors based on machine learning.

BMC neurology
BACKGROUND: ICU-acquired weakness (ICU-AW) is a common complication among ICU patients. We used machine learning techniques to construct an ICU-AW inflammatory factor prediction model to predict the risk of disease development and reduce the incidenc...

Combined inflammation-related biomarkers and clinicopathological features for the prognosis of stage II/III colorectal cancer by machine learning.

BMC cancer
BACKGROUND: Inflammation-related biomarkers, such as systemic inflammation score (SIS) and neutrophil-lymphocyte ratio (NLR), are associated with colorectal cancer prognosis. However, the combined role of SIS, NLR, and clinicopathological factors in ...

Machine learning approach identifies inflammatory gene signature for predicting survival outcomes in hepatocellular carcinoma.

Scientific reports
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, often linked to chronic inflammation. Our study aimed to probe inflammation pathways at the genetic level and pinpoint biomarkers linked to HCC patient ...

Discovery of Active Ingredient of Yinchenhao Decoction Targeting TLR4 for Hepatic Inflammatory Diseases Based on Deep Learning Approach.

Interdisciplinary sciences, computational life sciences
Yinchenhao Decoction (YCHD), a classic formula in traditional Chinese medicine, is believed to have the potential to treat liver diseases by modulating the Toll-like receptor 4 (TLR4) target. Therefore, a thorough exploration of the effective compone...

Machine learning algorithms using the inflammatory prognostic index for contrast-induced nephropathy in NSTEMI patients.

Biomarkers in medicine
Inflammatory prognostic index (IPI), has been shown to be related with poor outcomes in cancer patients. We aimed to investigate the predictive role of IPI for contrast-induced nephropathy (CIN) development in non-ST segment elevation myocardial inf...

Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats.

Archives of endocrinology and metabolism
OBJECTIVE: This study aims to explore the role of estrogen in providing cardioprotective benefits to premenopausal women, examining how hormonal differences between sexes influence the prevalence of cardiovascular diseases (CVDs) in women.