AIMC Topic: Interferon-gamma
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A hybrid method for discovering interferon-gamma inducing peptides in human and mouse.
Scientific reports
Nov 6, 2024
Interferon-gamma (IFN-γ) is a versatile pleiotropic cytokine essential for both innate and adaptive immune responses. It exhibits both pro-inflammatory and anti-inflammatory properties, making it a promising therapeutic candidate for treating various...
Differential plasma cytokine variation following X-ray or proton brain irradiation using machine-learning approaches.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Sep 21, 2024
PURPOSE: X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, suggesting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences i...
Multicolor-Assay-on-a-Chip Processed by Robotic Operation (MACpro) with Improved Diagnostic Accuracy for Field-Deployable Detection.
Analytical chemistry
Apr 15, 2024
The ability to deploy decentralized laboratories with autonomous and reliable disease diagnosis holds the potential to deliver accessible healthcare services for public safety. While microfluidic technologies provide precise manipulation of small flu...
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets.
Scientific reports
Jul 23, 2021
COVID-19 outbreak brings intense pressure on healthcare systems, with an urgent demand for effective diagnostic, prognostic and therapeutic procedures. Here, we employed Automated Machine Learning (AutoML) to analyze three publicly available high thr...
Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ-stimulated mesenchymal stromal cells that predict immunosuppression.
Cytotherapy
Nov 28, 2018
BACKGROUND: Although a preponderance of pre-clinical data demonstrates the immunosuppressive potential of mesenchymal stromal cells (MSCs), significant heterogeneity and lack of critical quality attributes (CQAs) based on immunosuppressive capacity l...
Evaluation of serum and salivary interferon-γ levels in patients with oral lichen planus: a systematic review and meta-analysis of case-control studies.
Oral surgery, oral medicine, oral pathology and oral radiology
Nov 24, 2018
OBJECTIVE: Cytokines have regulatory and leading roles in the immunopathogenesis of oral lichen planus (OLP). Here, we present the findings of a meta-analysis that evaluated serum and salivary interferon-γ (IFN-γ) levels in patients with OLP compared...
A multicentre verification study of the QuantiFERON-TB Gold Plus assay.
Tuberculosis (Edinburgh, Scotland)
Nov 28, 2017
OBJECTIVES: The aim of this verification study was to compare the QuantiFERON-TB Gold Plus (QFT-Plus) to the QuantiFERON-TB Gold In Tube (QFT-GIT). The new QFT-Plus test contains an extra antigen tube which, according to the manufacturer additionally...
Latent Tuberculosis
Belgium
Antigens, Bacterial
Interferon-gamma Release Tests
Mycobacterium tuberculosis
Netherlands
Host-Pathogen Interactions
Interferon-gamma
Female
Reproducibility of Results
Adult
Humans
Male
Middle Aged
CD8-Positive T-Lymphocytes
Predictive Value of Tests
CD4-Positive T-Lymphocytes
Histone deacetylase 2 is decreased in peripheral blood pro-inflammatory CD8+ T and NKT-like lymphocytes following lung transplant.
Respirology (Carlton, Vic.)
Nov 6, 2016
BACKGROUND AND OBJECTIVE: Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro-inflammatory cytokines in peripheral b...
Serum profile of cytokines interferon gamma and interleukin-10 in ewes subjected to artificial insemination by cervical retraction.
Theriogenology
Dec 23, 2015
This study evaluated the influence of artificial insemination (AI) by cervical retraction (CRI) on serum levels of interferon gamma (IFNγ) and interleukin-10 (IL-10) in ewes. Synchronized pluriparous Santa Inês ewes were subjected to natural mating (...
Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus.
Journal of diabetes research
Dec 6, 2015
This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (album...
ADAMTS13 Protein
Humans
Interleukin-10
Adolescent
Young Adult
Diabetic Nephropathies
Adult
Tumor Necrosis Factor-alpha
von Willebrand Factor
Male
Diabetes Mellitus, Type 1
Interleukin-6
Interferon-gamma
Albuminuria
Renal Insufficiency, Chronic
Middle Aged
Biomarkers
Fibrin Fibrinogen Degradation Products
ADAM Proteins
Female
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