AIMC Topic: Liver Cirrhosis
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Therapeutic horizons in metabolic dysfunction-associated steatohepatitis.
The Journal of clinical investigation
Jul 1, 2025
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory form of MASLD, is now a leading cause of chronic liver disease worldwide. Driven by obesity and type 2 diabetes, MASH significantly increases the risk of cirrhosis,...
Automated quantification of T1 and T2 relaxation times in liver mpMRI using deep learning: a sequence-adaptive approach.
European radiology experimental
Jun 14, 2025
OBJECTIVES: To evaluate a deep learning sequence-adaptive liver multiparametric MRI (mpMRI) assessment with validation in different populations using total and segmental T1 and T2 relaxation time maps.
Large Scale MRI Collection and Segmentation of Cirrhotic Liver.
Scientific data
May 28, 2025
Liver cirrhosis represents the end stage of chronic liver disease, characterized by extensive fibrosis and nodular regeneration that significantly increases mortality risk. While magnetic resonance imaging (MRI) offers a non-invasive assessment, accu...
Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.
Nature communications
May 15, 2025
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
Assessing the diagnostic accuracy of ChatGPT-4 in the histopathological evaluation of liver fibrosis in MASH.
Hepatology communications
Apr 30, 2025
BACKGROUND: Large language models like ChatGPT have demonstrated potential in medical image interpretation, but their efficacy in liver histopathological analysis remains largely unexplored. This study aims to assess ChatGPT-4-vision's diagnostic acc...
Precision Strike Strategy for Liver Diseases Trilogy with Xiao-Chai-Hu Decoction: A Meta-Analysis with Machine Learning.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 23, 2025
BACKGROUND AND PURPOSE: The progression from hepatitis to liver fibrosis (LF) and ultimately to hepatic carcinoma (HCC) represents the advanced stages of various liver diseases. Currently, no universal treatment effectively addresses all three condit...
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease.
Nature
Apr 16, 2025
Protein misfolding diseases, including α1-antitrypsin deficiency (AATD), pose substantial health challenges, with their cellular progression still poorly understood. We use spatial proteomics by mass spectrometry and machine learning to map AATD in h...
Machine learning-based integration reveals reliable biomarkers and potential mechanisms of NASH progression to fibrosis.
Scientific reports
Apr 11, 2025
Non-alcoholic fatty liver disease (NAFLD) affects about 25% of adults worldwide. Its advanced form, non-alcoholic steatohepatitis (NASH), is a major cause of liver fibrosis, but there are no non-invasive tests for diagnosing or preventing it. In our ...
Characterization of fibrotic liver tissue microstructure for predicting shear wave speed variability: a machine-learning-based computational study.
Physics in medicine and biology
Apr 11, 2025
This study aimed to establish a link between the microstructure of simulated fibrotic liver tissues and the measured shear wave speed (SWS) variability using a machine-learning (ML)-based approach.. Fibrotic liver tissues were simulated using biphasi...
Development of an explainable prediction model for portal vein system thrombosis post-splenectomy in patients with cirrhosis.
BMJ health & care informatics
Apr 10, 2025
BACKGROUND: Portal vein system thrombosis (PVST) is a common and potentially life-threatening complication following splenectomy plus pericardial devascularisation (SPDV) in patients with cirrhosis and portal hypertension. Early prediction of PVST is...
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