AIMC Topic: Liver Cirrhosis

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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Ritonavir Adolescent Macrocyclic Compounds Drug Therapy, Combination Ribavirin Antiviral Agents Drug Administration Schedule Hepatitis C, Chronic Sustained Virologic Response Genotype Anilides Valine Liver Cirrhosis Carbamates Young Adult Humans Treatment Outcome Adult Lactams, Macrocyclic Female Sulfonamides Follow-Up Studies Male Aged Cyclopropanes Middle Aged Aged, 80 and over Egypt Hepacivirus Administration, Oral Proline
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Integrative Analysis of Proteomic, Glycomic, and Metabolomic Data for Biomarker Discovery.

IEEE journal of biomedical and health informatics May 27, 2016
Studies associating changes in the levels of multiple biomolecules including proteins, glycans, glycoproteins, and metabolites with the onset of cancer have been widely investigated to identify clinically relevant diagnostic biomarkers. Advances in l...
Neoplasms Liver Neoplasms Computational Biology Liver Cirrhosis Support Vector Machine Humans Biomarkers Sensitivity and Specificity Diagnosis, Differential
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Machine Learning Classification of Cirrhotic Patients with and without Minimal Hepatic Encephalopathy Based on Regional Homogeneity of Intrinsic Brain Activity.

PloS one Mar 15, 2016
Machine learning-based approaches play an important role in examining functional magnetic resonance imaging (fMRI) data in a multivariate manner and extracting features predictive of group membership. This study was performed to assess the potential ...
Liver Cirrhosis Support Vector Machine Magnetic Resonance Imaging Hepatic Encephalopathy Female Adult Male Middle Aged Nerve Net Humans Machine Learning Brain
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The impact of paracentesis flow rate in patients with liver cirrhosis on the development of paracentesis induced circulatory dysfunction.

Clinical and molecular hepatology Dec 24, 2015
BACKGROUND/AIMS: Ascites is a dreadful complication of liver cirrhosis associated with short survival. Large volume paracentesis (LVP) is used to treat tense or refractory ascites. Paracentesis induced circulatory dysfunction (PICD) develops if no pl...
International Normalized Ratio Renin Humans Creatinine Aged Logistic Models Female Arteries Sex Factors Shock Adult Enzyme-Linked Immunosorbent Assay Paracentesis Male Liver Cirrhosis Middle Aged Blood Pressure
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Pulse Diagnosis Signals Analysis of Fatty Liver Disease and Cirrhosis Patients by Using Machine Learning.

TheScientificWorldJournal Nov 28, 2015
OBJECTIVE: . To compare the signals of pulse diagnosis of fatty liver disease (FLD) patients and cirrhosis patients.
Humans Machine Learning Liver Cirrhosis Models, Theoretical Algorithms Pulse Case-Control Studies Diagnosis, Computer-Assisted Fatty Liver
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Serum tests, liver stiffness and artificial neural networks for diagnosing cirrhosis and portal hypertension.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Feb 7, 2015
BACKGROUND: The diagnostic performance of biochemical scores and artificial neural network models for portal hypertension and cirrhosis is not well established.
Platelet Count Elasticity Imaging Techniques Hypertension, Portal Neural Networks, Computer Algorithms Female Aged Liver Cirrhosis Male Humans Liver Middle Aged Esophageal and Gastric Varices
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Analyses of a cirrhotic patient's evolution using self organizing mapping and Child-Pugh scoring.

Journal of medical systems Feb 3, 2015
Due to the importance of cirrhosis evolution, this study examined cirrhotic patients using Self Organizing Mapping (SOM) based on the Child-Pugh scoring method. Because Colored Doppler Ultrasound (CDU) has too many parameters, scoring can be a very d...
Male Middle Aged Liver Cirrhosis Age Factors Sex Factors Ultrasonography, Doppler, Color Neural Networks, Computer Female Aged Adult Humans
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Enhancing HF-DL Model Validation for Liver Fibrosis Staging Through Sample Optimisation and Technical Integration.

Liver international : official journal of the International Association for the Study of the Liver Aug 1, 2025
We read with great interest the article by Zhang et al. The study demonstrates that the deep learning model based on high-frequency ultrasound images significantly outperforms the low-frequency ultrasound model, FIB-4, APRI, and shear wave elastograp...
Ultrasonography Humans Liver Liver Cirrhosis Severity of Illness Index Deep Learning Hepatitis B, Chronic Elasticity Imaging Techniques
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Digital Pathology Quantification of the Continuum of Cirrhosis Severity in Human Liver Biopsies.

Liver international : official journal of the International Association for the Study of the Liver Jul 1, 2025
BACKGROUND AND AIMS: Liver biopsy is the gold standard for assessing fibrosis in cirrhotic livers, yet cirrhosis is spatially heterogeneous and continuously remodels. This study evaluates a novel phenotypic digital pathology platform for continuous f...
Liver Cirrhosis Liver Biopsy Adult Liver Transplantation Male Humans Middle Aged Female Severity of Illness Index Aged Biopsy, Needle
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A Deep Learning Model Based on High-Frequency Ultrasound Images for Classification of Different Stages of Liver Fibrosis.

Liver international : official journal of the International Association for the Study of the Liver Jul 1, 2025
BACKGROUND AND AIMS: To develop a deep learning model based on high-frequency ultrasound images to classify different stages of liver fibrosis in chronic hepatitis B patients.
Deep Learning Ultrasonography Liver Cirrhosis Liver Adult Male Middle Aged Severity of Illness Index Algorithms Hepatitis B, Chronic Retrospective Studies Humans Female
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