Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and d...
Infective endocarditis, a life-threatening condition, poses challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we performed proteomic profiling of plasma an...
OBJECTIVES: This study investigated association between long-term PM exposure and lung cancer incidence, focusing on Jiangsu Province, China. We aimed to explore the effects of historical PM with time lags and build a prediction model using machine l...
Outlier detection is essential for identifying unusual patterns or observations that significantly deviate from the normal behavior of a dataset. With the rapid growth of data science, the prevalence of anomalies and outliers has increased, which can...
Prostate cancer (PCa) is a major, and increasingly global, health concern with current screening and diagnostic tools' severe limitations causing unnecessary, invasive biopsy procedures. While gas chromatography-mass spectrometry (GC-MS) has been use...
Journal of chemical information and modeling
May 29, 2025
The self-aggregation of amyloid-β (Aβ) into fibrils is a hallmark of Alzheimer's disease (AD). Inhibition of Aβ aggregation with small molecule compounds represents a promising therapeutic strategy for AD. However, designing effective ligands is chal...
Journal of the American Chemical Society
May 29, 2025
This manuscript presents machine learning models for Pd-catalyzed C-N couplings constructed using a large, pharmaceutically relevant, structurally diverse dataset (4204 unique products) generated using high-throughput experimentation. The dataset ge...
Reliable prediction of pathogenic variants plays a crucial role in personalized medicine, which aims to provide accurate diagnosis and individualized treatment using genomic medicine. This study introduces PRP, a pathogenic risk prediction for rare n...
BACKGROUND: The global malaria burden is characterized by economic, geographical, and climatic disparities, especially in sub-Saharan Africa (SSA). Moreover, meteorological factors have become increasingly important to understand the malaria burden i...
Ischemic stroke (IS) is a multifactorial disease caused by the interaction of a variety of environmental and genetic factors, which can lead to severe disability and heavy social burden. This study aimed to find potential biomarkers related to T cell...
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