Identifying flavonoids in herbs is of great significance for elucidating their biological activity and pharmacological effects. However, distinguishing and detecting multiple flavonoids simultaneously remains a challenge. Here, an innovative citric a...
BACKGROUND: Since the approval of disease-modifying drugs for Alzheimer's disease, the demand for amyloid positron emission tomography (PET) scans, which are crucial for determining treatment eligibility, is expected to increase significantly. We thu...
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread use and bioaccumulative potential. Short-chain PFAS such as perfluorohexanoic acid (PFHxA) and perfluorohexane sulfonate (PFHxS) have been introduced...
PURPOSE OF REVIEW: Despite the pivotal role of randomized controlled trials (RCTs) in critical care research, many have failed to demonstrate significant benefits, particularly in nutrition interventions. This review highlights how patient heterogene...
Sepsis is a non-discriminatory inflammatory reaction that can result in a diverse array of organ dysfunctions, which can be fatal. Pyroptosis is a programmed mechanism of cell death that is distinguishable from apoptosis and other forms of cellular d...
Journal of environmental radioactivity
May 2, 2025
With the rapid increase in the number of nuclear power plants along the China coast and the potential for releases of radioactive substances to marine ecosystems, it is important to investigate and predict the dispersion of radionuclides in the seas ...
Sjogren's Disease (SjD) is an autoimmune disorder characterized by salivary and lacrimal gland dysfunction and immune cell infiltration leading to gland inflammation and destruction. Although SjD is a common disease, its pathogenesis is not fully und...
Machine learning-based stroke lesion segmentation models are widely used in biomedical imaging, but their ability to detect treatment effects remains largely unexplored. Gaussian Mixture Models (GMM) and nnU-Net are among the most prominent and well-...
UNLABELLED: Gihawi et al. (mBio 14:e01607-23, 2023, https://doi.org/10.1128/mbio.01607-23) argued that the analysis of tumor-associated microbiome data by Poore et al. (Nature 579:567-574, 2020, https://doi.org/10.1038/s41586-020-2095-1) is invalid b...
Proceedings of the National Academy of Sciences of the United States of America
May 2, 2025
Understanding the effects of missense mutations or single amino acid variants (SAVs) on protein function is crucial for elucidating the molecular basis of diseases/disorders and designing rational therapies. We introduce here , a machine learning too...
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