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Comparing lesion segmentation methods in multiple sclerosis: Input from one manually delineated subject is sufficient for accurate lesion segmentation.

NeuroImage. Clinical
PURPOSE: Accurate lesion segmentation is important for measurements of lesion load and atrophy in subjects with multiple sclerosis (MS). International MS lesion challenges show a preference of convolutional neural networks (CNN) strategies, such as n...

Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes.

Journal of neurointerventional surgery
BACKGROUND AND AIMS: Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS emboli and to assess associ...

Predicting individual decision-making responses based on single-trial EEG.

NeuroImage
Decision-making plays an essential role in the interpersonal interactions and cognitive processing of individuals. There has been increasing interest in being able to predict an individual's decision-making response (i.e., acceptance or rejection). W...

Big Data Challenges Targeting Proteins in GPCR Signaling Pathways; Combining PTML-ChEMBL Models and [S]GTPγS Binding Assays.

ACS chemical neuroscience
G-protein-coupled receptors (GPCRs), also known as 7-transmembrane receptors, are the single largest class of drug targets. Consequently, a large amount of preclinical assays having GPCRs as molecular targets has been released to public sources like ...

Statistical and machine learning methodology for abdominal aortic aneurysm prediction from ultrasound screenings.

Echocardiography (Mount Kisco, N.Y.)
A method of analysis of a database of patients (n = 10 329) screened for an abdominal aortic aneurysm (AAA) is presented. Self-reported height, weight, age, gender, ethnicity, and parameters "Heart Problems," "Hypertension," "High Cholesterol," "Diab...

Resting-State Functional Network Scale Effects and Statistical Significance-Based Feature Selection in Machine Learning Classification.

Computational and mathematical methods in medicine
In recent years, functional brain network topological features have been widely used as classification features. Previous studies have found that network node scale differences caused by different network parcellation definitions significantly affect...