Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe th...
Primary liver cancer is the sixth most commonly diagnosed cancer globally and the third leading cause of cancer-related deaths. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and microvascular invasion (MVI) is a sign...
Assessing MGMT promoter methylation is crucial for determining appropriate glioblastoma therapy. Previous studies have focused on intratumoral regions, overlooking the peritumoral area. This study aimed to develop a radiomic model using MRI-derived f...
BACKGROUND: This paper explores the perception and application of artificial intelligence (AI) for personalized medicine within the trans community, an often-overlooked demographic in the broader scope of precision medicine. Despite growing advanceme...
BACKGROUND: Autonomous sensory meridian response (ASMR) videos have been increasingly popularized as accessible tools for stress relief. Despite widespread media coverage promoting their benefits, empirical research on the neural mechanisms underlyin...
Perioperative neurocognitive disorders (PND) are linked to neuroinflammation, a key factor in hypertension, but their causal relationship is underexplored. This study aims to investigate whether hypertension is a risk factor for PND, identify related...
BACKGROUND: The opioid crisis in the United States is a complex issue with interconnected factors that lead to opioid misuse and opioid-involved mortality. This study assessed the relative importance of different risk factor domains in predicting fat...
Chest X-ray (CXR) imaging plays a pivotal role in the diagnosis and prognosis of viral pneumonia. However, distinguishing COVID-19 CXRs from other viral infections remains challenging due to highly similar radiographic features. Most existing deep le...
BACKGROUND: Early warning signals (EWS) based on dynamical systems theory, such as increased autocorrelation (AR) and variance, may indicate impending mood episodes in bipolar disorder (BD). This study examines whether smartphone-based digital phenot...
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