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Deep learning and whole-brain networks for biomarker discovery: modeling the dynamics of brain fluctuations in resting-state and cognitive tasks.

Scientific reports
Brain network models offer insights into brain dynamics, but the utility of model-derived bifurcation parameters as biomarkers remains underexplored. This study evaluates bifurcation parameters from a whole-brain network model as biomarkers for disti...

Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry.

Nature communications
Prostate cancer (PrCa) incidence and severity vary across ancestries; men of African ancestry (AA) are more likely to be diagnosed and die from PrCa than those of European ancestry (EA). Current polygenic risk scores, even from multi-ancestry GWAS, d...

Evaluating ChatGPT-4o as an Educational Support Tool for the Emergency Management of Dental Trauma: Randomized Controlled Study Among Students.

JMIR medical education
BACKGROUND: Digital tools are increasingly used to support clinical decision-making in dental education. However, the accuracy and efficiency of different support tools, including generative artificial intelligence, in the context of dental trauma ma...

Leveraging Large Language Models to Identify Engagement-Driving Features in Vaping-Related TikTok Videos: Cross-Sectional Study.

Journal of medical Internet research
BACKGROUND: Electronic cigarette (e-cigarette) use is prevalent in youth and young adults in the United States. TikTok (ByteDance), a popular social media platform among youth and young adults, has become a key avenue for disseminating e-cigarette-re...

Teaching Clinical Reasoning in Health Care Professions Learners Using AI-Generated Script Concordance Tests: Mixed Methods Formative Evaluation.

JMIR formative research
BACKGROUND: The integration of artificial intelligence (AI) in medical education is evolving, offering new tools to enhance teaching and assessment. Among these, script concordance tests (SCTs) are well-suited to evaluate clinical reasoning in contex...

Web-Based AI-Driven Virtual Patient Simulator Versus Actor-Based Simulation for Teaching Consultation Skills: Multicenter Randomized Crossover Study.

JMIR formative research
BACKGROUND: There is a need to increase health care professional training capacity to meet global needs by 2030. Effective communication is essential for delivering safe and effective patient care. Artificial intelligence (AI) technologies may provid...

Predicting the timing of LC after PTGBD in elderly patients with acute cholecystitis: a machine learning approach with a web-based calculator.

Langenbeck's archives of surgery
BACKGROUND: Transcutaneous transhepatic gallbladder drainage (PTGBD) has shown significant efficacy in the treatment of elderly patients with acute cholecystitis. The goal of this study is to develop a machine learning-based web calculator aimed at p...

Efficacy and safety of ureteroscopy in children with lower pole renal stones : a machine learning predictive model from the EAU section of endourology.

World journal of urology
INTRODUCTION: The rising incidence of kidney stone disease in children presents growing clinical challenges, particularly in managing lower pole (LP) calculi, which are anatomically difficult to treat. Flexible ureteroscopy with laser lithotripsy (fU...

Effects of environment and globalization on the double and triple burdens of infection symptoms among under-five children across low-middle income countries using machine learning algorithms.

Infectious diseases of poverty
BACKGROUND: Childhood infectious diseases and related symptoms, such as fever, cough, and diarrhea among children constitute the leading cause of death in low and middle-income countries (LMICs). We examined the environmental predictors of double and...

IGFBP7 and CCT2 are novel lactylation-driven mediators of endothelial-to-mesenchymal transition in idiopathic pulmonary fibrosis.

Functional & integrative genomics
Lactylation is a post-translational modification that can influence the onset and progression of various diseases.However, its role in Idiopathic Pulmonary Fibrosis (IPF) has not been systematically investigated. Single-cell sequencing and bulk RNA s...