AIMC Topic: MCF-7 Cells
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PHENOLIC PROFILE OF L. GROWING IN EGYPT AND ITS CYTOTOXIC AND ANTIVIRAL ACTIVITIES.
African journal of traditional, complementary, and alternative medicines : AJTCAM
Sep 29, 2016
BACKGROUND: L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constituents. This study represents the first in-depth characterization of the phenolic profile of the aeria...
Label-free and dynamic evaluation of cell-surface epidermal growth factor receptor expression via an electrochemiluminescence cytosensor.
Talanta
Dec 18, 2015
A label-free electrochemiluminescence (ECL) cytosensor was developed for dynamically evaluating of epidermal growth factor receptor (EGFR) expression on MCF-7 cancer cells based on the specific recognition of epidermal growth factor (EGF) with its re...
Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner.
BMC medical genomics
Dec 18, 2015
BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is requi...
Inferring Association between Compound and Pathway with an Improved Ensemble Learning Method.
Molecular informatics
Aug 6, 2015
Emergence of compound molecular data coupled to pathway information offers the possibility of using machine learning methods for compound-pathway associations' inference. To provide insights into the global relationship between compounds and their af...
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Environmental toxicology
Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
Gold
Humans
Membrane Potential, Mitochondrial
Female
Platinum
Proto-Oncogene Proteins c-bcl-2
Breast Neoplasms
Acetylcysteine
Real-Time Polymerase Chain Reaction
Reactive Oxygen Species
Down-Regulation
Caspase 9
RNA, Messenger
Caspase 3
Up-Regulation
G1 Phase Cell Cycle Checkpoints
Apoptosis
Particle Size
Nanotubes
MCF-7 Cells
Scientific hypothesis generation by large language models: laboratory validation in breast cancer treatment.
Journal of the Royal Society, Interface
Jun 1, 2025
Large language models (LLMs) have transformed artificial intelligence (AI) and achieved breakthrough performance on a wide range of tasks. In science, the most interesting application of LLMs is for hypothesis formation. A feature of LLMs, which resu...
Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics.
Bioinformatics (Oxford, England)
Dec 22, 2021
MOTIVATION: Motions of transmembrane receptors on cancer cell surfaces can reveal biophysical features of the cancer cells, thus providing a method for characterizing cancer cell phenotypes. While conventional analysis of receptor motions in the cell...
A sequence-based deep learning approach to predict CTCF-mediated chromatin loop.
Briefings in bioinformatics
Sep 2, 2021
Three-dimensional (3D) architecture of the chromosomes is of crucial importance for transcription regulation and DNA replication. Various high-throughput chromosome conformation capture-based methods have revealed that CTCF-mediated chromatin loops a...
Locating transcription factor binding sites by fully convolutional neural network.
Briefings in bioinformatics
Sep 2, 2021
Transcription factors (TFs) play an important role in regulating gene expression, thus identification of the regions bound by them has become a fundamental step for molecular and cellular biology. In recent years, an increasing number of deep learnin...
Volatile constituents and in vitro activity of Syzygium aromaticum flower buds (clove) against human cancer cell lines.
Pakistan journal of pharmaceutical sciences
Nov 1, 2020
The methanolic extract (SA-EXT) of Syzygium aromaticum flower buds and its fractions tested against three human cancer cell lines viz uterine cervix (HeLa), breast (MCF-7) and lung NCI (H-460) using sulforhodamine-B assay. The ethyl acetate soluble s...
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