AIMC Topic: Metformin

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Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer.

Oncotarget Apr 18, 2017
We demonstrate that model-based unsupervised learning can uniquely discriminate single-cell subpopulations by their gene expression distributions, which in turn allow us to identify specific genes for focused functional studies. This method was appli...
Cluster Analysis Unsupervised Machine Learning Signal Transduction Cell Movement Gene Knockdown Techniques cdc42 GTP-Binding Protein AMP-Activated Protein Kinases Metformin Gene Expression Profiling Cell Line, Tumor Computational Biology Gene Expression Regulation, Neoplastic Female Breast Neoplasms Humans
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Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination.

Die Pharmazie Feb 1, 2017
A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical combination Kazano® tablets, was developed and compared to a new UHPLC-UV method (method B). Concerni...
Tablets Chromatography, High Pressure Liquid Tandem Mass Spectrometry Spectrometry, Mass, Electrospray Ionization Hypoglycemic Agents Drug Combinations Sensitivity and Specificity Uracil Metformin Piperidines
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Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Jan 1, 2017
Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages in cardiovascular protection with a low risk of hypoglycemia. Few studies have measured lactic acid ...
Diabetic Nephropathies Hypoglycemic Agents Renal Insufficiency, Chronic Treatment Outcome Case-Control Studies Diabetes Mellitus, Type 2 Middle Aged Risk Assessment Bicarbonates Acidosis, Lactic Metformin Lactic Acid Hydrogen-Ion Concentration Administration, Oral Humans Risk Factors Male Biomarkers Female
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Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.

Iranian journal of allergy, asthma, and immunology Dec 1, 2016
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...
NF-kappa B AMP-Activated Protein Kinases Lipopolysaccharides Blotting, Western Toll-Like Receptor 4 Peroxidase Metformin Myeloid Differentiation Factor 88 RNA, Messenger Rats, Wistar Rats Hypoglycemic Agents Lung Real-Time Polymerase Chain Reaction Male Acute Lung Injury Tumor Necrosis Factor-alpha Animals
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