AIMC Topic: Mice
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A robust deep learning approach for segmenting cortical and trabecular bone from 3D high resolution µCT scans of mouse bone.
Scientific reports
Mar 13, 2025
Recent advancements in deep learning have significantly enhanced the segmentation of high-resolution microcomputed tomography (µCT) bone scans. In this paper, we present the dual-branch attention-based hybrid network (DBAHNet), a deep learning archit...
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning.
eLife
Mar 13, 2025
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their sparse distribu...
Liquid-bodied antibiofilm robot with switchable viscoelastic response for biofilm eradication on complex surface topographies.
Science advances
Mar 12, 2025
Recalcitrant biofilm infections pose a great challenge to human health. Micro- and nanorobots have been used to eliminate biofilm infections in hard-to-reach regions inside the body. However, applying antibiofilm robots under physiological conditions...
Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.
Computational biology and chemistry
Mar 11, 2025
BACKGROUND: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflamm...
Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.
Cellular signalling
Mar 11, 2025
OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute panc...
Unraveling the power of NAP-CNB's machine learning-enhanced tumor neoantigen prediction.
eLife
Mar 11, 2025
In this study, we present a proof-of-concept classical vaccination experiment that validates the in silico identification of tumor neoantigens (TNAs) using a machine learning-based platform called NAP-CNB. Unlike other TNA predictors, NAP-CNB leverag...
CPHNet: a novel pipeline for anti-HAPE drug screening via deep learning-based Cell Painting scoring.
Respiratory research
Mar 8, 2025
BACKGROUND: High altitude pulmonary edema (HAPE) poses a significant medical challenge to individuals ascending rapidly to high altitudes. Hypoxia-induced cellular morphological changes in the alveolar-capillary barrier such as mitochondrial structur...
EVlncRNA-net: A dual-channel deep learning approach for accurate prediction of experimentally validated lncRNAs.
International journal of biological macromolecules
Mar 6, 2025
Long non-coding RNAs (lncRNAs) play key roles in numerous biological processes and are associated with various human diseases. High-throughput RNA sequencing (HTlncRNAs) has identified tens of thousands of lncRNAs across species, but only a small fra...
Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder.
Life sciences
Mar 5, 2025
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disu...
Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.
ACS nano
Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
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