Messenger RNA (mRNA) therapeutics hold significant potential across a wide range of medical applications. LNPs are the most clinically advanced mRNA delivery vehicles, but challenges such as off-target effects and liver accumulation limit their broad...
BACKGROUND: Triacylglycerols (TGs) are the most abundant lipids in the human body and the primary source of energy storage. TGs are comprised of three fatty acyls with various lengths and double bond composition, complicating structural annotation wh...
UNLABELLED: The gut microbiota plays a crucial role in maintaining host health, and its composition is significantly influenced by aging. The SAMP8 mouse model, known for its accelerated aging process, is widely used to study age-related changes. How...
Partitioning cells in open nanowells permits high confidence in single cell occupancy and enables flexibility in the development of different molecular assays. A challenge for this approach however is to print cells sufficiently quickly to enable exp...
The corticospinal tract (CST) is essential for forelimb-specific fine motor skills. In rodents, it undergoes extensive structural remodeling across development, injury, and disease states, with major implications for motor function. A vast body of li...
Proceedings of the National Academy of Sciences of the United States of America
Sep 22, 2025
remains a leading cause of hospital-acquired infections, with its primary virulence factor, toxin B (TcdB), responsible for severe colitis and recurrent disease. The closely related toxin, TcsL, from , causes a rarer but often fatal toxic shock synd...
Bone cancer pain (BCP) is a complex condition that severely affects patients' quality of life, and its treatment remains challenging. Astaxanthin, a potent antioxidant with anti-inflammatory and neuroprotective effects, and celecoxib, a selective COX...
To address the toxicity of current microtubule inhibitors, we employed the GeminiMol deep learning model to screen the Zinc20 database, identifying a novel 4,5-dihydropyrrolo[3,4-]pyrazol-6(2)-one scaffold () targeting the colchicine binding site. Su...
BACKGROUND: Chronic allergic rhinitis and asthma syndrome (CARAS) is a comorbid inflammatory condition affecting both upper and lower airways, with limited treatment options. Artesunate (ART), a derivative of artemisinin, has shown anti-inflammatory ...
Targeting therapeutic nanoparticles to the brain poses a challenge due to the restrictive nature of the blood-brain barrier (BBB). Here we report the development of mRNA-loaded lipid nanoparticles (LNPs) functionalized with BBB-interacting small mole...
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