AIMC Topic: Mice

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Automated analysis of a novel object recognition test in mice using image processing and machine learning.

Behavioural brain research Sep 30, 2024
The novel object recognition test (NORT) is one of the most commonly employed behavioral tests in experimental animals designed to evaluate an animal's interest in and recognition of novelty. However, manual procedures, which rely on researchers' obs...
Recognition, Psychology Machine Learning Animals Male Mice, Inbred C57BL Image Processing, Computer-Assisted Behavior, Animal Mice Exploratory Behavior Support Vector Machine
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Learning to segment self-generated from externally caused optic flow through sensorimotor mismatch circuits.

Neural networks : the official journal of the International Neural Network Society Sep 28, 2024
Efficient sensory detection requires the capacity to ignore task-irrelevant information, for example when optic flow patterns created by egomotion need to be disentangled from object perception. To investigate how this is achieved in the visual syste...
Mice Models, Neurological Visual Pathways Neural Networks, Computer Visual Cortex Neurons Learning Motion Perception Visual Perception Animals Optic Flow
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Capture of RNA-binding proteins across mouse tissues using HARD-AP.

Nature communications Sep 28, 2024
RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism, but a comprehensive picture of RBP expression across tissues is lacking. Here, we describe our development of the method we call HARD-AP that robustly retrieves RBPs and tightly asso...
Humans Machine Learning Mice RNA-Binding Proteins Animals RNA Protein Binding Binding Sites
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Identification of common biomarkers in diabetic kidney disease and cognitive dysfunction using machine learning algorithms.

Scientific reports Sep 27, 2024
Cognitive dysfunction caused by diabetes has become a serious global medical issue. Diabetic kidney disease (DKD) exacerbates cognitive dysfunction in patients, although the precise mechanism behind this remains unclear. Here, we conducted an investi...
Gene Expression Profiling Cognitive Dysfunction Mice Machine Learning Algorithms Diabetic Nephropathies Biomarkers Neurons Humans Animals
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A Practical Method for Predicting Compound Brain Concentration-Time Profiles: Combination of PK Modeling and Machine Learning.

Molecular pharmaceutics Sep 26, 2024
Given the aging populations in advanced countries globally, many pharmaceutical companies have focused on developing central nervous system (CNS) drugs. However, due to the blood-brain barrier, drugs do not easily reach the target area in the brain. ...
Central Nervous System Agents Tissue Distribution Machine Learning Drug Discovery Computer Simulation Brain Mice Blood-Brain Barrier Models, Biological Animals
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Machine learning-based discovery of UPP1 as a key oncogene in tumorigenesis and immune escape in gliomas.

Frontiers in immunology Sep 24, 2024
INTRODUCTION: Gliomas are the most common and aggressive type of primary brain tumor, with a poor prognosis despite current treatment approaches. Understanding the molecular mechanisms underlying glioma development and progression is critical for imp...
Cell Line, Tumor Mice Gene Expression Regulation, Neoplastic Biomarkers, Tumor Oncogenes Glioma Humans Brain Neoplasms Tumor Escape Carcinogenesis Machine Learning Animals Prognosis
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Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs.

Nature methods Sep 23, 2024
Transposon (IS200/IS605)-encoded TnpB proteins are predecessors of class 2 type V CRISPR effectors and have emerged as one of the most compact genome editors identified thus far. Here, we optimized the design of Deinococcus radiodurans (ISDra2) TnpB ...
RNA, Guide, CRISPR-Cas Systems Deinococcus HEK293 Cells Gene Editing DNA Transposable Elements Humans Mice CRISPR-Cas Systems Animals Deep Learning
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Differential plasma cytokine variation following X-ray or proton brain irradiation using machine-learning approaches.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique Sep 21, 2024
PURPOSE: X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, suggesting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences i...
Machine Learning Cytokines Male Mice Mice, Inbred C57BL Principal Component Analysis Brain Female Animals Interleukin-1alpha Proton Therapy Protons Cranial Irradiation Chemokine CCL2 Interleukin-12 Interferon-gamma
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Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases.

Journal of medicinal chemistry Sep 20, 2024
The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable human diseases, making it an urgent target for therapeutic intervention. Here, we report the development of SN3-1, a novel orally potent NLRP3 inhibitor, designed ...
Inflammasomes Crystallography, X-Ray Mice, Inbred C57BL Structure-Activity Relationship NLR Family, Pyrin Domain-Containing 3 Protein Humans Animals Male Mice Inflammation Drug Discovery Deep Learning
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Nanorobot-Based Direct Implantation of Flexible Neural Electrode for BCI.

IEEE transactions on bio-medical engineering Sep 19, 2024
Brain-Computer Interface (BCI) has gained remarkable prominence in biomedical community. While BCI holds vast potential across diverse domains, the implantation of neural electrodes poses multifaceted challenges to fully explore the power of BCI. Con...
Brain Animals Equipment Design Mice Nanotechnology Brain-Computer Interfaces Robotics Electrodes, Implanted Electroencephalography
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