AIMC Topic: Mice
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Neurons throughout the brain embed robust signatures of their anatomical location into spike trains.
eLife
Jun 27, 2025
Neurons in the brain are known to encode diverse information through their spiking activity, primarily reflecting external stimuli and internal states. However, whether individual neurons also embed information about their own anatomical location wit...
Optogenetic neural spheroids excite primary neural network.
Journal of neural engineering
Jun 26, 2025
Optical stimulation ofneurons requires prior transfection with light gated ion channels. This additional step brings complexity and requires optimization. Simplification of the process will ease the undertaking of studies on biological neural network...
Accurate Tracking of Locomotory Kinematics in Mice Moving Freely in Three-Dimensional Environments.
eNeuro
Jun 25, 2025
Marker-based motion capture (MBMC) is a powerful tool for precise, high-speed, three-dimensional tracking of animal movements, enabling detailed study of behaviors ranging from subtle limb trajectories to broad spatial exploration. Despite its proven...
CellSeg3D, Self-supervised 3D cell segmentation for fluorescence microscopy.
eLife
Jun 24, 2025
Understanding the complex three-dimensional structure of cells is crucial across many disciplines in biology and especially in neuroscience. Here, we introduce a set of models including a 3D transformer (SwinUNetR) and a novel 3D self-supervised lear...
Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.
The journal of headache and pain
Jun 23, 2025
BACKGROUND: Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas...
Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury.
Signal transduction and targeted therapy
Jun 23, 2025
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underlying molec...
Transcriptomic analysis reveals novel targets in benign schwannoma using machine learning.
Neuroscience
Jun 21, 2025
BACKGROUND & OBJECTIVE: This study aimed to identify key immune-related biomarkers of benign schwannoma through machine learning-assisted transcriptomic and single-cell analyses, and to construct a predictive model for disease evaluation.
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy.
Pharmacological research
Jun 19, 2025
Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challeng...
Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.
Nature communications
Jun 18, 2025
Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed...
Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.
Science translational medicine
Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
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