AIMC Topic: Middle Aged

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Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

PloS one
BACKGROUND: Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions are charact...

Kcc-ReHo and Cohe-ReHo in bipolar disorder: their associated genes and potential for diagnosis and treatment prediction.

Neuropharmacology
The neural mechanisms underlying resting-state cerebral functional activity in bipolar disorder (BD) and the effects of pharmacotherapy on it remain unclear. This study investigated changes in local brain activity in BD patients (BDPs) following trea...

Artificial Intelligence for Identification of Patients with Increased Risk of Severe Cancer Therapy-Related Cardiac Dysfunction Following Anthracycline Therapy.

The American journal of medicine
BACKGROUND: Early detection of cancer therapy-related cardiac dysfunction (CTRCD) after anthracycline exposure is critically important in minimizing morbidity and mortality. Artificial intelligence models applied to electrocardiograms (ECG-AI) may al...

Multi-parameter MRI deep learning model for lymphovascular invasion assessment in invasive breast ductal carcinoma: A multicenter, retrospective study.

Clinical radiology
AIMS: To investigate the value of multi-parametric magnetic resonance imaging (MRI)-based deep learning (DL) in predicting the Lymphovascular Invasion (LVI) status of invasive breast ductal cancer (IBDC).

Micronutrient supplementation influences the composition and diet-originating function of the gut microbiome in healthy adults.

Clinical nutrition (Edinburgh, Scotland)
BACKGROUND & AIMS: Studies in-vitro and in animals propose that vitamins and minerals can alter the human gut microbiome. Human trials replicating these findings are scarce or used micronutrient supplementation in supraphysiological doses. We explore...

Predicting complications in breast reconstruction: External validation of a machine learning model.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS
BACKGROUND: Nipple-sparing mastectomy (NSM) with immediate implant-based breast reconstruction provides aesthetic and psychosocial benefits, but nipple-areolar complex (NAC) necrosis remains a significant risk. This study externally validated a previ...

Computed tomography-derived quantitative imaging biomarkers enable the prediction of disease manifestations and survival in patients with systemic sclerosis.

RMD open
INTRODUCTION: Systemic sclerosis (SSc) is a complex inflammatory vasculopathy with diverse symptoms and variable disease progression. Despite its known impact on body composition (BC), clinical decision-making has yet to incorporate these biomarkers....

Impact of mHealth on Postoperative Quality of Life, Self-Management, and Dysfunction in Patients With Oral and Maxillofacial Tumors: Nonrandomized Controlled Trial.

JMIR mHealth and uHealth
BACKGROUND: With a focus on postoperative dysfunctions that may occur after maxillofacial tumor resection and the difficulties faced during home rehabilitation, we developed a mobile health app based on nurse-patient cooperation. The app extends reha...

Using a Multilingual AI Care Agent to Reduce Disparities in Colorectal Cancer Screening for Higher Fecal Immunochemical Test Adoption Among Spanish-Speaking Patients: Retrospective Analysis.

Journal of medical Internet research
BACKGROUND: Colorectal cancer (CRC) screening rates remain disproportionately low among Hispanic and Latino populations compared to non-Hispanic White populations. While artificial intelligence (AI) shows promise in health care delivery, concerns exi...

Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.

Journal of neurology
INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.