AIMC Topic: Models, Biological
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Biological age prediction using a DNN model based on pathways of steroidogenesis.
Science advances
Mar 14, 2025
Aging involves the progressive accumulation of cellular damage, leading to systemic decline and age-related diseases. Despite advances in medicine, accurately predicting biological age (BA) remains challenging due to the complexity of aging processes...
Machine learning-derived diagnostic model of epithelial ovarian cancer based on gut microbiome signatures.
Journal of translational medicine
Mar 13, 2025
BACKGROUND: Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value of gut microbiota in epithelial ovarian cancer remains insufficiently investi...
Control of medical digital twins with artificial neural networks.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Mar 13, 2025
The objective of precision medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be personalized and dyn...
Predicting the diversity of photosynthetic light-harvesting using thermodynamics and machine learning.
PLoS computational biology
Mar 11, 2025
Oxygenic photosynthesis is responsible for nearly all biomass production on Earth, and may have been a prerequisite for establishing a complex biosphere rich in multicellular life. Life on Earth has evolved to perform photosynthesis in a wide range o...
RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling.
Scientific reports
Mar 7, 2025
The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate approaches in developing controlled-release rivaroxaban (RVX) osmotic tablets. The influence of dif...
Using deep reinforcement learning to investigate stretch feedback during swimming of the lamprey.
Bioinspiration & biomimetics
Mar 5, 2025
Animals have to navigate complex environments and perform intricate swimming maneuvers in the real world. To conquer these challenges, animals evolved a variety of motion control strategies. While it is known that many factors contribute to motion co...
Novel augmentation techniques using diffusion models for green wall plant health classification.
Computers in biology and medicine
Mar 4, 2025
Green walls, vertical plant-based structures, are increasingly popular due to their diverse environmental benefits, including aesthetic enhancement, temperature and humidity regulation, and air pollutant removal. These systems, typically consisting o...
Estimation of Ganciclovir Exposure in Adults Transplant Patients by Machine Learning.
The AAPS journal
Feb 28, 2025
INTRODUCTION: Valganciclovir, a prodrug of ganciclovir (GCV), is used to prevent cytomegalovirus infection after transplantation, with doses adjusted based on creatinine clearance (CrCL) to target GCV AUC0-24 h of 40-60 mg*h/L. This sometimes leads t...
Nonlocal models in biology and life sciences: Sources, developments, and applications.
Physics of life reviews
Feb 27, 2025
Mathematical modeling is one of the fundamental techniques for understanding biophysical mechanisms in developmental biology. It helps researchers to analyze complex physiological processes and connect like a bridge between theoretical and experiment...
Modeling and optimization of docosahexaenoic acid production by Schizochytrium sp. based on kinetic modeling and genetic algorithm optimized artificial neural network.
Bioresource technology
Feb 22, 2025
Docosahexaenoic acid (DHA), an essential ω-3 polyunsaturated fatty acid, is efficiently biosynthesized by Schizochytrium sp., yet its bioprocess optimization remains constrained by dynamic interdependencies between cultivation parameters and metaboli...
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