Modelling biological systems depends on the availability of data and components of the system at hand. As our understanding of these systems evolves, the ability to gradually refine models by adding new components of different formalisms covering sto...
INTRODUCTION: Valganciclovir, a prodrug of ganciclovir (GCV), is used to prevent cytomegalovirus infection after transplantation, with doses adjusted based on creatinine clearance (CrCL) to target GCV AUC0-24 h of 40-60 mg*h/L. This sometimes leads t...
This study compares the efficacy of machine learning models to traditional biophysical models in predicting rectal (T) and skin (T) temperatures of older adults (≥60 years) during prolonged heat exposure. Five machine learning models were trained on ...
Docosahexaenoic acid (DHA), an essential ω-3 polyunsaturated fatty acid, is efficiently biosynthesized by Schizochytrium sp., yet its bioprocess optimization remains constrained by dynamic interdependencies between cultivation parameters and metaboli...
Integrating genome-scale metabolic networks with reactive transport models (RTMs) provides a detailed description of the dynamic changes in microbial growth and metabolism. Despite promising demonstrations in the past, computational inefficiency has ...
Wing articulation is critical for the efficient flight of bird- and bat-sized animals. Inspired by the flight of , the lesser short-nosed fruit bat, we built a two-degree-of-freedom flapping wing platform with variable wing folding capability. In the...
With the ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its increasing adaptation to humans, several variants of concern (VOCs) and variants of interest (VOIs) have been identified since late 2020. These include...
IEEE transactions on bio-medical engineering
40030364
This paper proposes a method to learn approximations of missing Ordinary Differential Equations (ODEs) and states in physiological models where knowledge of the system's relevant states and dynamics is incomplete. The proposed method augments known O...
For years, a main focus of ecological research has been to better understand the complex dynamical interactions between species that comprise food webs. Using the connectance properties of a widely explored synthetic food web called the cascade model...
Animals have to navigate complex environments and perform intricate swimming maneuvers in the real world. To conquer these challenges, animals evolved a variety of motion control strategies. While it is known that many factors contribute to motion co...