AI Medical Compendium Topic:
Models, Biological

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Pressure redistributing in-seat movement activities by persons with spinal cord injury over multiple epochs.

PloS one
Pressure ulcers, by definition, are caused by external forces on the tissues, often in the regions of bony prominences. Wheelchair users are at risk to develop sitting-acquired pressure ulcers, which occur in the regions of the ischial tuberosities, ...

An attention based deep learning model of clinical events in the intensive care unit.

PloS one
This study trained long short-term memory (LSTM) recurrent neural networks (RNNs) incorporating an attention mechanism to predict daily sepsis, myocardial infarction (MI), and vancomycin antibiotic administration over two week patient ICU courses in ...

Predicting inadequate postoperative pain management in depressed patients: A machine learning approach.

PloS one
Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSRIs), inhibits CYP-2D6 activity...

Optimal adaptive control of drug dosing using integral reinforcement learning.

Mathematical biosciences
In this paper, a reinforcement learning (RL)-based optimal adaptive control approach is proposed for the continuous infusion of a sedative drug to maintain a required level of sedation. To illustrate the proposed method, we use the common anesthetic ...

An Effective Solution for Large Scale Single Machine Total Weighted Tardiness Problem using Lunar Cycle Inspired Artificial Bee Colony Algorithm.

IEEE/ACM transactions on computational biology and bioinformatics
Single machine total weighted tardiness problem (SMTWTP) is one of the fundamental combinatorial optimization problems. The problem consists of a set of independent jobs with distinct processing times, weights, and due dates to be scheduled on a sing...

A Torque-actuated dissipative spring loaded inverted pendulum model with rolling contact and Its application to hexapod running.

Bioinspiration & biomimetics
We report on the development and analysis of a new torque-actuated dissipative spring loaded inverted pendulum model with rolling contact (TDR-SLIP), which is a successor to the previously developed spring loaded inverted pendulum model with rolling ...

Elasticity Versus Hyperelasticity Considerations in Quasistatic Modeling of a Soft Finger-Like Robotic Appendage for Real-Time Position and Force Estimation.

Soft robotics
Various methods based on hyperelastic assumptions have been developed to address the mathematical complexities of modeling motion and deformation of continuum manipulators. In this study, we propose a quasistatic approach for 3D modeling and real-tim...

Predictive Multitask Deep Neural Network Models for ADME-Tox Properties: Learning from Large Data Sets.

Journal of chemical information and modeling
Successful drug discovery projects require control and optimization of compound properties related to pharmacokinetics, pharmacodynamics, and safety. While volume and chemotype coverage of public and corporate ADME-Tox (absorption, distribution, excr...

Robotic device shows lack of momentum enhancement for gymnotiform swimmers.

Bioinspiration & biomimetics
Many fish generate thrust by undulating one or multiple elongated fins while keeping their body straight. This propulsion mechanism has stimulated interest in both biology and bio-inspired marine propulsion because its maneuverability and efficiency ...

A unifying framework for interpreting and predicting mutualistic systems.

Nature communications
Coarse-grained rules are widely used in chemistry, physics and engineering. In biology, however, such rules are less common and under-appreciated. This gap can be attributed to the difficulty in establishing general rules to encompass the immense div...