AIMC Topic: Nanoparticles

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Stability of infliximab solutions in different temperature and dilution conditions.

Journal of pharmaceutical and biomedical analysis Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Antirheumatic Agents Protein Aggregates Spectrophotometry, Ultraviolet Chromatography, Gel Chromatography, Ion Exchange Nephelometry and Turbidimetry Peptide Mapping Time Factors Drug Compounding Nanoparticles Osmolar Concentration Spectroscopy, Fourier Transform Infrared Pharmaceutical Solutions Infliximab Technology, Pharmaceutical Biosimilar Pharmaceuticals Temperature Protein Stability Drug Stability
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Salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers selectively suppress human CD20+ melanoma stem cells.

Acta pharmacologica Sinica Dec 14, 2017
Melanoma is the deadliest type of skin cancer. CD20+ melanoma stem cells (CSCs) are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20+ melanoma CSCs represents an effective treatment to eradicate melanoma. Sa...
Particle Size Drug Carriers Polyethylene Glycols Lecithins Aptamers, Nucleotide Nanoparticles Neoplastic Stem Cells Mice, Inbred BALB C Xenograft Model Antitumor Assays Antigens, CD20 Pyrans Humans Melanoma Animals Antineoplastic Agents
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Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.

Journal of environmental sciences (China) Nov 7, 2017
As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, ...
Fluorocarbons Toxicity Tests Metal Nanoparticles Fluorocarbon Polymers Nanoparticles Polymethyl Methacrylate Reactive Oxygen Species DNA Damage Cell Survival Cell Death Alkanesulfonic Acids
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Machine Learning for Silver Nanoparticle Electron Transfer Property Prediction.

Journal of chemical information and modeling Oct 5, 2017
Nanoparticles exhibit diverse structural and morphological features that are often interconnected, making the correlation of structure/property relationships challenging. In this study a multi-structure/single-property relationship of silver nanopart...
Nanoparticles Models, Chemical Silver Electron Transport Machine Learning
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Probing the toxicity of nanoparticles: a unified in silico machine learning model based on perturbation theory.

Nanotoxicology Sep 22, 2017
Nanoparticles (NPs) are part of our daily life, having a wide range of applications in engineering, physics, chemistry, and biomedicine. However, there are serious concerns regarding the harmful effects that NPs can cause to the different biological ...
Animals Risk Assessment Nanoparticles Models, Theoretical Humans Neural Networks, Computer Machine Learning Computer Simulation Predictive Value of Tests Quantitative Structure-Activity Relationship Toxicity Tests
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Fluorescence resonance energy transfer aptasensor between nanoceria and graphene quantum dots for the determination of ochratoxin A.

Analytica chimica acta Aug 24, 2017
In the present work, colloidal cerium oxide nanoparticles (nanoceria) and graphene quantum dots (GQDs) were firstly synthesized by sol-gel method and pyrolysis respectively, which all have a uniform nano-size and significant fluorescence emission. Du...
Aptamers, Nucleotide Nanoparticles Ochratoxins Quantum Dots Graphite Fluorescence Resonance Energy Transfer
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A neural controller for online laser power adjustment during the heat therapy process in the presence of nanoparticles.

Australasian physical & engineering sciences in medicine Apr 10, 2017
The present research evaluated the efficiency of a control approach to control the temperature of a breast tumor mass in the presence of nanoparticles exposed to laser radiation. However, if the radiation is carried out in open loop manner it may res...
Time Factors Neural Networks, Computer Nanoparticles Nanotechnology Computer Simulation Models, Theoretical Lasers Quantum Dots Temperature Hyperthermia, Induced Fluorescence Online Systems
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Statistical optimization and artificial neural network modeling for acridine orange dye degradation using in-situ synthesized polymer capped ZnO nanoparticles.

Journal of colloid and interface science Jan 13, 2017
ZnO NPs were synthesized by a prudent green chemistry approach in presence of polyacrylamide grafted guar gum polymer (pAAm-g-GG) to ensure uniform morphology, and functionality and appraised for their ability to degrade photocatalytically Acridine O...
Neural Networks, Computer Algorithms Nanoparticles Polymers Zinc Oxide Acridine Orange
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Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.

Journal of colloid and interface science Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Micelles Prodrugs HeLa Cells Hydrophobic and Hydrophilic Interactions Polyethylene Glycols Hydrolysis Solubility Drug Liberation Fumarates Polypropylenes Surface Properties Ibuprofen Anhydrides Animals Nanoparticles Cell Line Cell Survival Drug Carriers Anti-Inflammatory Agents, Non-Steroidal Rabbits Hydrogen-Ion Concentration Humans
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Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Integrin alphaVbeta3 Corneal Neovascularization Eye Burns Catechin Molecular Targeted Therapy Oligopeptides Angiogenesis Inhibitors Disease Models, Animal Mice, Inbred C57BL Cell Survival Burns, Chemical Human Umbilical Vein Endothelial Cells Ophthalmic Solutions Hyaluronic Acid Humans Animals Nanoparticles
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