AIMC Topic: Nanoparticles
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Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells.
Materials science & engineering. C, Materials for biological applications
Dec 18, 2015
Metallic nanoparticles often attribute severe adverse effects to the various organs or tissues at the molecular level despite of their applications in medical, laboratory and industrial sectors. The present study highlights the preparation of copper ...
Methodological considerations for using umu assay to assess photo-genotoxicity of engineered nanoparticles.
Mutation research. Genetic toxicology and environmental mutagenesis
Nov 24, 2015
In this study we investigated the feasibility of high-throughput (96-well plate) umu assay to test the genotoxic effect of TiO2 engineered nanoparticles (ENPs) under UV light (full spectrum) and visible light (455 nm). Exposure of TiO2 ENPs to up to ...
Magnetic nanoparticles and nanocomposites for remote controlled therapies.
Journal of controlled release : official journal of the Controlled Release Society
Sep 25, 2015
This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of M...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Poloxamer
Polysorbates
Solubility
Nanomedicine
Neural Networks, Computer
Polymers
Technology, Pharmaceutical
Nanoparticles
Kinetics
Particle Size
Chemistry, Pharmaceutical
Verapamil
Surface Properties
Lipids
Algorithms
Delayed-Action Preparations
Calcium Channel Blockers
Drug Carriers
Computer Simulation
Models, Chemical
A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity.
Drug delivery
Feb 26, 2015
Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined...
Size Control in the Nanoprecipitation Process of Stable Iodine (¹²⁷I) Using Microchannel Reactor-Optimization by Artificial Neural Networks.
AAPS PharmSciTech
Feb 6, 2015
In this study, nanosuspension of stable iodine ((127)I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was eval...
A hybrid artificial neural network and particle swarm optimization for prediction of removal of hazardous dye brilliant green from aqueous solution using zinc sulfide nanoparticle loaded on activated carbon.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Sep 22, 2014
In the present study, zinc sulfide nanoparticle loaded on activated carbon (ZnS-NP-AC) simply was synthesized in the presence of ultrasound and characterized using different techniques such as SEM and BET analysis. Then, this material was used for br...
Toxicity of nanoplastics: machine learning combined with meta-analysis.
Nanoscale horizons
Aug 21, 2025
Nanoplastics (NPs) are widespread in ecosystems, and their biohazards are of increasing concern. The hazards posed by NPs to aquatic and terrestrial plants as well as to aquatic animals have been extensively studied; however, their impact on mammals ...
Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.
Journal of controlled release : official journal of the Controlled Release Society
Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
Serum-Based Detection of Pancreatic and Ovarian Cancer via a Nanoparticle-Enhanced Fluorescence Array and Machine Learning.
Analytical chemistry
Jul 8, 2025
: Early detection of oncological diseases such as pancreatic ductal adenocarcinoma (PDAC) and ovarian cancer (OV) is pivotal for successful treatment but remains a significant challenge due to the lack of sensitive and specific diagnostic tests. Fluo...
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