AIMC Topic: Neurodegenerative Diseases
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Clinical validation of artificial intelligence-based single-subject morphometry without normative reference database.
Journal of Alzheimer's disease : JAD
Jan 12, 2025
BACKGROUND: Single-subject voxel-based morphometry (VBM) is a powerful technique for reader-independent detection of brain atrophy in structural magnetic resonance imaging (MRI) to support the (differential) diagnosis and staging of neurodegenerative...
Step Width Estimation in Individuals With and Without Neurodegenerative Disease via a Novel Data-Augmentation Deep Learning Model and Minimal Wearable Inertial Sensors.
IEEE journal of biomedical and health informatics
Jan 7, 2025
Step width is vital for gait stability, postural balance control, and fall risk reduction. However, estimating step width typically requires either fixed cameras or a full kinematic body suit of wearable inertial measurement units (IMUs), both of whi...
Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning: The Brain-Predicted Disease Duration Gap.
Neurology
Nov 4, 2024
BACKGROUND AND OBJECTIVES: Disentangling brain aging from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but may miss disease-specific eff...
Unlocking therapeutic frontiers: harnessing artificial intelligence in drug discovery for neurodegenerative diseases.
Drug discovery today
Oct 18, 2024
Neurodegenerative diseases (NDs) pose serious healthcare challenges with limited therapeutic treatments and high social burdens. The integration of artificial intelligence (AI) into drug discovery has emerged as a promising approach to address these ...
A computational and machine learning approach to identify GPR40-targeting agonists for neurodegenerative disease treatment.
PloS one
Oct 8, 2024
The G protein-coupled receptor 40 (GPR40) is known to exert a significant influence on neurogenesis and neurodevelopment within the central nervous system of both humans and rodents. Research findings indicate that the activation of GPR40 by an agoni...
Integrating large-scale single-cell RNA sequencing in central nervous system disease using self-supervised contrastive learning.
Communications biology
Sep 10, 2024
The central nervous system (CNS) comprises a diverse range of brain cell types with distinct functions and gene expression profiles. Although single-cell RNA sequencing (scRNA-seq) provides new insights into the brain cell atlases, integrating large-...
An efficient ranking-based ensembled multiclassifier for neurodegenerative diseases classification using deep learning.
Journal of neural transmission (Vienna, Austria : 1996)
Sep 9, 2024
Neurodegenerative diseases are group of debilitating and progressive disorders that primarily affect the structure and functions of nervous system, leading to gradual loss of neurons and subsequent decline in cognitive, and behavioral activities. The...
An Innovative Device Based on Human-Machine Interface (HMI) for Powered Wheelchair Control for Neurodegenerative Disease: A Proof-of-Concept.
Sensors (Basel, Switzerland)
Jul 23, 2024
In the global context, advancements in technology and science have rendered virtual, augmented, and mixed-reality technologies capable of transforming clinical care and medical environments by offering enhanced features and improved healthcare servic...
Advances in Computational Biology for Diagnosing Neurodegenerative Diseases: A Comprehensive Review.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Jul 2, 2024
The numerous and varied forms of neurodegenerative illnesses provide a considerable challenge to contemporary healthcare. The emergence of artificial intelligence has fundamentally changed the diagnostic picture by providing effective and early means...
Autophagy and machine learning: Unanswered questions.
Biochimica et biophysica acta. Molecular basis of disease
May 25, 2024
Autophagy is a critical conserved cellular process in maintaining cellular homeostasis by clearing and recycling damaged organelles and intracellular components in lysosomes and vacuoles. Autophagy plays a vital role in cell survival, bioenergetic ho...
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