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Patient Selection

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Clinical trial cohort selection based on multi-level rule-based natural language processing system.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Identifying patients who meet selection criteria for clinical trials is typically challenging and time-consuming. In this article, we describe our clinical natural language processing (NLP) system to automatically assess patients' eligibil...

Hybrid bag of approaches to characterize selection criteria for cohort identification.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: The 2018 National NLP Clinical Challenge (2018 n2c2) focused on the task of cohort selection for clinical trials, where participating systems were tasked with analyzing longitudinal patient records to determine if the patients met or did n...

Optimizing clinical trials recruitment via deep learning.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Clinical trials, prospective research studies on human participants carried out by a distributed team of clinical investigators, play a crucial role in the development of new treatments in health care. This is a complex and expensive proce...

Criteria2Query: a natural language interface to clinical databases for cohort definition.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Cohort definition is a bottleneck for conducting clinical research and depends on subjective decisions by domain experts. Data-driven cohort definition is appealing but requires substantial knowledge of terminologies and clinical data mode...

Machine Learning Algorithm Helps Identify Non-Diagnosed Prodromal Alzheimer's Disease Patients in the General Population.

The journal of prevention of Alzheimer's disease
BACKGROUND: Recruiting patients for clinical trials of potential therapies for Alzheimer's disease (AD) remains a major challenge, with demand for trial participants at an all-time high. The AD treatment R and D pipeline includes around 112 agents. I...

SemEHR: A general-purpose semantic search system to surface semantic data from clinical notes for tailored care, trial recruitment, and clinical research.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Unlocking the data contained within both structured and unstructured components of electronic health records (EHRs) has the potential to provide a step change in data available for secondary research use, generation of actionable medical i...

EliIE: An open-source information extraction system for clinical trial eligibility criteria.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: To develop an open-source information extraction system called Eligibility Criteria Information Extraction (EliIE) for parsing and formalizing free-text clinical research eligibility criteria (EC) following Observational Medical Outcomes P...