AIMC Topic: Polyethylene Glycols
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Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules.
Analytical chemistry
Nov 30, 2016
Sensitive determination of the pharmacokinetics of PEGylated molecules can accelerate the process of drug development. Here, we combined different anti-PEG Fab expressing 293T cells as capture cells (293T/3.3, 293T/6.3, and 293T/15-2b cells) with fou...
Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line.
Journal of environmental sciences (China)
Jul 13, 2016
The antibacterial potential of silver nanoparticles (AgNPs) resulted in their increasing incorporation into consumer, industrial and biomedical products. Therefore, human and environmental exposure to AgNPs (either as an engineered product or a conta...
Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests.
Advanced materials (Deerfield Beach, Fla.)
Nov 25, 2015
Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot ...
An investigation into the usefulness of different empirical modeling techniques for better control of spray-on fluidized bed melt granulation.
International journal of pharmaceutics
Nov 10, 2015
Melt granulation in fluid bed processors is an emerging technique, but literature data regarding the modeling of this granulation method are lacking. In the present study different techniques (response surface analysis, multilayer perceptron neural n...
Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.
Drug development and industrial pharmacy
Jun 11, 2015
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solven...
The effects of environmental and compositional manipulations on the longevity of Tessari-made foam for sclerotherapy.
Journal of vascular surgery. Venous and lymphatic disorders
Sep 4, 2014
BACKGROUND: Tessari-made foam sclerotherapy is performed around the world in a variety of clinics differing in methods, equipment, temperatures, and altitudes. We investigated how the following factors affected the foam's longevity: silicone vs nonsi...
[A study of the clinical curative effect of nucleos(t)ide analogues treated to pegylated interferon-α add-on therapy in patients with chronic hepatitis B].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Dec 20, 2023
To investigate the hepatitis B surface antigen (HBsAg) clearance condition and its predictive factors after treatment with nucleos(t)ide analogues to pegylated interferon-α add-on therapy in patients with chronic hepatitis B. Patients with chronic ...
Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients.
Acta gastro-enterologica Belgica
Jan 1, 2018
BACKGROUND AND STUDY AIMS: In an exploratory study we compared a new regimen of low-volume polyethylene glycol plus ascorbic acid (PEG-Asc) with the standard regimen for same-day bowel cleansing in constipated patients.
Fabrication, Characterization, and Hemocompatibility Investigation of Polysulfone Grafted With Polyethylene Glycol and Heparin Used in Membrane Oxygenators.
Artificial organs
Nov 1, 2016
Polysulfone (PSF) was grafted chemically with polyethylene glycol (PEG) of different molecular weights (400, 2000, 10 000, and 20 000) and heparin to prepare PSF-PEG-Hep membranes (labeled as PSF-PEG400-Hep, PSF-PEG2000-Hep, PSF-PEG10 000-Hep, and PS...
[Process Optimization of PEGylating Fused Protein of LL-37 and Interferon-α2a].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Dec 1, 2015
PEGylating is an effective way for prolonging the half-time period and decreasing the immunogenicity of protein drugs. With experiments of single factor, it was proved that the optimal processes for PEGylating the fused protein of LL-37 and interfero...
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