Journal of cellular and molecular medicine
Aug 1, 2025
The immunoregulatory functions and clinical implications of APOE+ macrophages within the tumour microenvironment of lung adenocarcinoma remain incompletely defined. In this study, single-cell transcriptome analysis revealed distinct subsets of APOE+ ...
Thromboangiitis obliterans (TAO) is often diagnosed late and characterized by high amputation rates. TAO-specific early diagnostic and disease-staging biomarkers are urgently needed. A staged mass spectrometry (MS)-based discovery-verification-valida...
OBJECTIVE: Prognostication in patients with disorders of consciousness (DOCs) remains challenging because of heterogeneous etiologies, pathophysiologies and, consequently, highly variable electroencephalograms (EEGs). Here, we use EEG patterns that a...
BACKGROUND: Robotic central pancreatectomy is increasingly used for pre- or low-grade malignant tumors in the pancreatic body balancing preservation of pancreatic function while removing the target lesion. Today, there is no established reconstructio...
AIMS: Breast cancer has become the number 1 killer threatening women's health. In recent years, glycosylation modification has played an increasingly important role in tumor progression. The aim of this study was to explore the key genes that may be ...
Cancer survival prediction based on multimodal data (e.g., pathological slides, clinical records, and genomic profiles) has become increasingly prevalent in recent years. A key challenge of this task is obtaining an effective survival-specific global...
Journal of the American Medical Informatics Association : JAMIA
Aug 1, 2025
OBJECTIVES: Immunotherapies have revolutionized the landscape of cancer treatments. However, our understanding of response patterns in advanced cancers treated with immunotherapy remains limited. By leveraging routinely collected noninvasive longitud...
BACKGROUND: Visual scoring of tubular damage has limitations in capturing the full spectrum of structural changes and prognostic potential. Here, we investigated if computationally quantified tubular features can enhance prognostication and reveal sp...
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Aug 1, 2025
PURPOSE: To develop an integrative radiopathomic model based on deep learning to predict overall survival (OS) in locally advanced nasopharyngeal carcinoma (LANPC) patients.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Aug 1, 2025
BACKGROUND: The high-sensitivity C-reactive protein (Hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio, which integrates insights into inflammation and lipid metabolism, serves as a comprehensive indicator. The association between this ra...
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