AIMC Topic: Prognosis
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Radiomics applications in the modern management of esophageal squamous cell carcinoma.
Medical oncology (Northwood, London, England)
May 27, 2025
Esophageal cancer ranks among the most lethal malignancies globally, with China accounting for more than half of worldwide esophageal squamous cell carcinoma (ESCC) cases. Late-stage diagnosis frequently precludes surgical intervention, contributing ...
Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.
Frontiers in immunology
May 27, 2025
BACKGROUND: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activity. However, the role of NK c...
Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.
Frontiers in endocrinology
May 27, 2025
BACKGROUND: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhausti...
AI-based multimodal prediction of lymph node metastasis and capsular invasion in cT1N0M0 papillary thyroid carcinoma.
Frontiers in endocrinology
May 27, 2025
BACKGROUND: Accurate preoperative evaluation of cT1N0M0 papillary thyroid carcinoma (PTC) is essential for guiding appropriate treatment strategies. Although ultrasound is widely used for clinical staging, it has limitations in detecting lymph node m...
Identification of a novel chemotherapy benefit index for patients with advanced ovarian cancer based on Bayesian network analysis.
PloS one
May 27, 2025
BACKGROUND: This study aims to evaluate the efficacy of chemotherapy and optimize treatment strategies for patients with advanced ovarian cancer.
HGMSurvNet: A two-stage hypergraph learning network for multimodal cancer survival prediction.
Medical image analysis
May 23, 2025
Cancer survival prediction based on multimodal data (e.g., pathological slides, clinical records, and genomic profiles) has become increasingly prevalent in recent years. A key challenge of this task is obtaining an effective survival-specific global...
Leveraging Digital Twins for Stratification of Patients with Breast Cancer and Treatment Optimization in Geriatric Oncology: Multivariate Clustering Analysis.
JMIR cancer
May 23, 2025
BACKGROUND: Defining optimal adjuvant therapeutic strategies for older adult patients with breast cancer remains a challenge, given that this population is often overlooked and underserved in clinical research and decision-making tools.
Association between fibrinogen levels and prognosis in critically bleeding patients: exploration of the optimal therapeutic threshold.
European journal of trauma and emergency surgery : official publication of the European Trauma Society
May 23, 2025
BACKGROUND: Severe bleeding is a leading cause of ICU admission and mortality. Fibrinogen plays a crucial role in prognosis, yet optimal thresholds and supplementation targets remain unclear.
Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer.
Frontiers in immunology
May 23, 2025
INTRODUCTION: Pancreatic cancer (PC) remains a lethal malignancy with limited treatment options. The role of innate immune cell barrier-related genes in PC prognosis is poorly defined. This study aimed to identify prognostic biomarkers, develop a pre...
Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure.
Hereditas
May 22, 2025
BACKGROUND: Methylation of RNA is involved in many pathophysiological processes. The roles of N6-methyladenosine (m6A) and N7-methylguanosine (m7G) in heart failure (HF) have been established. However, the impact of 5-methylcytosine (m5C) on HF and i...
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