AIMC Topic: Protein Interaction Maps
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Bioinformatics Approach to Identifying Molecular Targets of Isoliquiritigenin Affecting Chronic Obstructive Pulmonary Disease: A Machine Learning Pharmacology Study.
International journal of molecular sciences
Apr 21, 2025
To identify the molecular targets and possible mechanisms of isoliquiritigenin (ISO) in affecting chronic obstructive pulmonary disease (COPD) by regulating the glycolysis and phagocytosis of alveolar macrophages (AM). Datasets GSE130928 and GSE13896...
Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis.
International dental journal
Apr 15, 2025
OBJECTIVE: While ferritinophagy is believed to play a significant role in the development of periodontitis, the exact mechanisms remain unclear. This study aimed to investigate the biomarkers associated with ferritinophagy in periodontitis using tran...
Identification of M1 macrophage infiltration-related genes for immunotherapy in Her2-positive breast cancer based on bioinformatics analysis and machine learning.
Scientific reports
Apr 11, 2025
Over the past several decades, there has been a significant increase in the number of breast cancer patients. Among the four subtypes of breast cancer, Her2-positive breast cancer is one of the most aggressive breast cancers. In this study, we screen...
Analysis and validation of hub genes for atherosclerosis and AIDS and immune infiltration characteristics based on bioinformatics and machine learning.
Scientific reports
Apr 10, 2025
Atherosclerosis is the major cause of cardiovascular diseases worldwide, and AIDS linked with chronic inflammation and immune activation, increases atherosclerosis risk. The application of bioinformatics and machine learning to identify hub genes for...
How did we get there? AI applications to biological networks and sequences.
Computers in biology and medicine
Apr 3, 2025
The rapidly advancing field of artificial intelligence (AI) has transformed numerous scientific domains, including biology, where a vast and complex volume of data is available for analysis. This paper provides a comprehensive overview of the current...
Identification of biomarkers associated with M1 macrophages in the ST-segment elevation myocardial infarction through bioinformatics and machine learning approaches.
Scientific reports
Apr 1, 2025
ST-segment elevation myocardial infarction (STEMI) is considered a critical cardiac condition with a poor prognosis. Shortly after STEMI occurs, the increased number of circulating leukocytes including macrophages can lead to the accumulation of more...
Association of the characteristics of brain magnetic resonance imaging with genes related to disease onset in schizophrenia patients.
SLAS technology
Mar 28, 2025
BACKGROUND: Schizophrenia (SCH) is a complex neurodevelopmental disorder, whose pathogenesis is not fully elucidated. This article aims to reveal disease-specific brain structural and functional changes and their potential genetic basis by analyzing ...
Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia.
Journal of chemical information and modeling
Mar 17, 2025
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agents that offer more precise and controllable effects. Targeting Gamma-a...
GALR1 and PENK serve as potential biomarkers in invasive non-functional pituitary neuroendocrine tumours.
Gene
Feb 28, 2025
BACKGROUND: Some nonfunctioning pituitary neuroendocrine tumor (NFPitNET) can show invasive growth, which increases the difficulty of surgery and indicates a poor prognosis. However, the molecular mechanism related to invasiveness remains to be furth...
Air pollution and prostate cancer: Unraveling the connection through network toxicology and machine learning.
Ecotoxicology and environmental safety
Feb 28, 2025
BACKGROUND: In recent years, air pollution has been demonstrated to be associated with the occurrence of various diseases. This study aims to explore the potential association between air pollutants and prostate cancer (PCa) and to identify key genes...
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