AIMC Topic: Randomized Controlled Trials as Topic

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Predicting Postoperative Circulatory Complications in Older Patients: A Machine Learning Approach.

Biomedical and environmental sciences : BES
OBJECTIVE: This study examines utilizes the advantages of machine learning algorithms to discern key determinants in prognosticate postoperative circulatory complications (PCCs) for older patients.

Effect of artificial intelligence driven therapeutic lifestyle changes (AI-TLC) intervention on health behavior and health among obesity pregnant women in China: a randomized controlled trial protocol.

Frontiers in public health
INTRODUCTION: Obesity has reached epidemic proportions globally, posing significant challenges to public health and economic stability. In China, the prevalence of obesity is increasing rapidly, particularly among pregnant women, who face unique risk...

Comparison of Different Machine Learning Methodologies for Predicting the Non-Specific Treatment Response in Placebo Controlled Major Depressive Disorder Clinical Trials.

Clinical and translational science
Placebo effect represents a serious confounder for the assessment of treatment effect to the extent that it has become increasingly difficult to develop antidepressant medications appropriate for outperforming placebo. Treatment effect in randomized,...

The 'golden fleece of embryology' eludes us once again: a recent RCT using artificial intelligence reveals again that blastocyst morphology remains the standard to beat.

Human reproduction (Oxford, England)
Grading of blastocyst morphology is used routinely for embryo selection with good outcomes. A lot of effort has been placed in IVF to search for the prize of selecting the most viable embryo to transfer ('the golden fleece of embryology'). To improve...

Artificial Intelligence in Cardiovascular Clinical Trials.

Journal of the American College of Cardiology
Randomized clinical trials are the gold standard for establishing the efficacy and safety of cardiovascular therapies. However, current pivotal trials are expensive, lengthy, and insufficiently diverse. Emerging artificial intelligence (AI) technolog...

Randomised controlled trials evaluating artificial intelligence in clinical practice: a scoping review.

The Lancet. Digital health
This scoping review of randomised controlled trials on artificial intelligence (AI) in clinical practice reveals an expanding interest in AI across clinical specialties and locations. The USA and China are leading in the number of trials, with a focu...

Effects of robot-assisted gait training on motor performance of lower limb in poststroke survivors: a systematic review with meta-analysis.

European review for medical and pharmacological sciences
OBJECTIVE: This study aimed to investigate the effects of robot-assisted gait training (RAGT) on improving walking ability, and to determine the optimal dosage of task-specific training based on RAGT for stroke patients.

Adaptive selection of the optimal strategy to improve precision and power in randomized trials.

Biometrics
Benkeser et al. demonstrate how adjustment for baseline covariates in randomized trials can meaningfully improve precision for a variety of outcome types. Their findings build on a long history, starting in 1932 with R.A. Fisher and including more re...

Combining Rule-based NLP-lite with Rapid Iterative Chart Adjudication for Creation of a Large, Accurately Curated Cohort from EHR data: A Case Study in the Context of a Clinical Trial Emulation.

AMIA ... Annual Symposium proceedings. AMIA Symposium
The aim of this work was to create a gold-standard curated cohort of 10,000+ cases from the Veteran Affairs (VA) corporate data warehouse (CDW) for virtual emulation of a randomized clinical trial (CSP#592). The trial had six inclusion/exclusion crit...

The Use of Large Language Models to Accelerate Literature Review Towards Digital Health Equity and Inclusiveness.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Digital health technologies (DHTs) have revolutionized clinical trials, offering unprecedented opportunities to streamline processes, enhance patient engagement, and improve data quality. Growing technology device and broadband access are contributin...