AIMC Topic: Rats, Sprague-Dawley

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Identification of inflammation-related biomarkers and therapeutic targets for neurogenic bladder fibrosis via multi-omics analysis.

Computers in biology and medicine
Inflammatory responses play a crucial role in the progression of pediatric neurogenic bladder (NB)-associated fibrosis; however, their specific contributions remain poorly understood. This study aimed to identify inflammation-related biomarkers for d...

Estimation of postmortem interval under different ambient temperatures based on multi-organ metabolomics and machine learning algorithm.

International journal of legal medicine
In forensic practice, the estimation of postmortem interval has been a persistent challenge. Recently, there has been an increasing utilization of metabolomics techniques combined with machine learning methods for postmortem interval estimation. When...

Integrating single-cell analysis and machine learning to identify COPD hub genes and explore the intervention mechanism of effective component compatibility of Bufei Yishen formula III.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a prevalent condition that poses a major threat to public health. Endothelial cells play a critical role in COPD pathogenesis. Recent evidence suggests that the effective...

Improving Imaging Field of View of 3-D Transcranial Rat Brain Super-Resolution With Robotic Registered Compounding and Nonrigid Deformation Correction.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Large field-of-view (FOV) brain imaging with ultrasound has become increasingly achievable with the application of 2-D probes capable of volumetric imaging. However, even in small animals the skull presents a significant barrier and conventional plan...

Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.

Cytokine
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...

A Novel Diffusion Irradiation Method to Monitor Thermal Effects on Deep Subcutaneous Vessels Using Laser Speckle Contrast Imaging.

Journal of biophotonics
This study aims to investigate the effects of upper skin layers on laser light propagation and heat diffusion during laser surgery for vascular dermatosis. Using a rat dorsal window chamber model, deep-situated vessels are irradiated by a transcutane...

Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression.

Function (Oxford, England)
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied. This study examined the effects of fentanyl and sufen...

Deep Eutectic Solvent Extraction Assisted Ligand Affinity Assay for α-Glucosidase Inhibitors Screening From the Plasma of Rats Administrated Pueraria lobata Extracts.

Journal of separation science
In this work, for the first time, a deep eutectic solvent assisted ligand affinity assay was proposed. Several critical parameters affecting the analysis performance were investigated and the optimized DES extract conditions were as follows: the solu...

Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.

Frontiers in immunology
AIM OF THE STUDY: To establish a cross-tissue bioinformatics model for identifying conserved key genes and immune infiltration mechanisms in ischemia-reperfusion injury (IRI) with experimental validation in limb IRI, including pharmacological targeti...

Mechanism of Zuogui pill enhancing ovarian function and skin elastic repair in premature aging rats based on artificial intelligence medical image analysis.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
BACKGROUND: AI medical image analysis shows potential applications in research on premature aging and skin. The purpose of this study was to explore the mechanism of the Zuogui pill based on artificial intelligence medical image analysis on ovarian f...